ArticleImmunogenetics1989
B-G cDNA clones have multiple small repeats and hybridize to both chicken MHC regions.
Article in Immunogenetics, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Functional Alleles of Chicken BG Genes, Members of the Butyrophilin Gene Family, in Peripheral T Cells.Frontiers in immunology · 2018Article
- Targeted capture enrichment and sequencing identifies extensive nucleotide variation in the turkey MHC-B.Immunogenetics · 2016Article
- Sequence of a complete chicken BG haplotype shows dynamic expansion and contraction of two gene lineages with particular expression patterns.PLoS genetics · 2014Article
- Extended sequence of the turkey MHC B-locus and sequence variation in the highly polymorphic B-G loci.Immunogenetics · 2011Article
- Two CD1 genes map to the chicken MHC, indicating that CD1 genes are ancient and likely to have been present in the primordial MHC.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The chicken beta 2-microglobulin gene is located on a non-major histocompatibility complex microchromosome: a small, G+C-rich gene with X and Y boxes in the promoter.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens.Immunogenetics · 1992Article
- Molecular genotyping of recombinant congenic lines provides evidence for crossing-over within the B-G region of the major histocompatibility complex of the chicken.Immunogenetics · 1992Article
- Immunoglobulin variable-region-like domains of diverse sequence within the major histocompatibility complex of the chicken.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Chicken major histocompatibility complex-encoded B-G antigens are found on many cell types that are important for the immune system.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Variations in the cytoplasmic region account for the heterogeneity of the chicken MHC class I (B-F) molecules.Immunogenetics · 1991Article
- Size polymorphism of chicken major histocompatibility complex-encoded B-G molecules is due to length variation in the cytoplasmic heptad repeat region.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- T cell precursor migration towards beta 2-microglobulin is involved in thymus colonization of chicken embryos.The EMBO journal · 1990Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequences in the chicken MHC as defined by congenic strains; the fusion proteins react with multiple immune but not preimmune sera, they select antibodies from the antisera to B-G, which then react with distinct erythrocyte B-G protein patterns, and they elicit antibodies from mice which in turn react with authentic B-G proteins. None of the clones represent a complete message, some--if not all--bear introns, and none of them match with any sequences presently stored in the data banks. The following new information did, however, emerge. At least two homologous transcripts are present in this homozygous chicken, thereby formally proving the existence of an expressed multigene family. The 3' ends (3'UT) are simple sequences with 80% nucleotide identity between clones, while the 5' ends (either coding or noncoding) are composed of multiple short repeats which are far less similar. These repeats could explain the bewildering variation in size of B-G proteins within and between haplotypes. Southern blots of genomic chicken DNA gave complex patterns for most probes, with many bands in common using different probes, but few bands in common between haplotypes. The sequences detected are all present in the MHC, based on the congenic lines CB and CC. Most of these sequences map into the B-G region, but some map into the B-F/B-L region as defined by the haplotypes B15, B21, and their apparently reciprocal recombinants B21r3 and B15r1.
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