ArticleObesity (Silver Spring, Md.)2015
Maternal adiposity negatively influences infant brain white matter development.
Article in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of neuroimaging epigenetic research: calling for an increased focus on development.Molecular psychiatry · 2023Pooled it
- Periconceptional biomarkers for maternal obesity: a systematic review.Reviews in endocrine & metabolic disorders · 2023Pooled it
- Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics.Pediatric research · 2026Article
- Maternal obesity and the embryonic rewiring of feeding circuits: Beyond the hypothalamus.Molecular metabolism · 2026Review
- Effortful Control and Cortical Brain Structure in 5-Year-Old Children: Findings From the FinnBrain Birth Cohort Study.The European journal of neuroscience · 2026Article
- Impact of physical activity and exercise interventions on white matter integrity in overweight and obese populations: A systematic review and meta-analysis.Comprehensive psychoneuroendocrinology · 2026Review
- Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study.BMC medicine · 2026Article
- The Peripheral Epigenome Predicts White Matter Volume Contingent on Developmental Stage: An ECHO Study.Molecular neurobiology · 2025Article
- Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring.Journal of neurochemistry · 2025Review
- Neurodevelopmental Pathways from Maternal Obesity to Offspring Outcomes: An Umbrella Review of Cognitive and Behavioral Consequences Across Development.Healthcare (Basel, Switzerland) · 2025Review
- Current states in understanding oligodendroglia-mediated neurological issues in neurofibromatosis type 1 (NF1).Acta neuropathologica communications · 2025Review
- Sex-specific white matter alterations in children exposed to high pregestational BMI.Obesity (Silver Spring, Md.) · 2025Article
- Associations between maternal pre-pregnancy BMI and mean diffusivity of the hippocampus and amygdala in infants.International journal of obesity (2005) · 2025Article
- Considering comorbidities: neurodevelopmental implications for children of diabetic mothers.Pediatric research · 2025Article
- Impact of high maternal body mass index on fetal cerebral cortical and cerebellar volumes.Journal of perinatal medicine · 2025Article
- Maternal Obesity and Neurodevelopment of the Offspring.Nutrients · 2025Review
- In Utero Alcohol and Tobacco Exposure, Maternal Depression, And Maternal Obesity Are Associated with Impaired Oligodendrocyte Differentiation in The Developing Brain.Obstetrics and gynecology research · 2025Article
- Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity.BMC medicine · 2024Article
- Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring.Journal of neuroinflammation · 2024Article
- Structural brain correlates of non-verbal cognitive ability in 5-year-old children: Findings from the FinnBrain birth cohort study.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo study potential effects of maternal body composition on central nervous system (CNS) development of newborn infants.
methodsDiffusion tensor imaging (DTI) was used to evaluate brain white matter development in 2-week-old, full-term, appropriate for gestational age (AGA) infants from uncomplicated pregnancies of normal-weight (BMI < 25 at conception) or obese ( BMI = 30 at conception) and otherwise healthy mothers. Tract-based spatial statistics (TBSS) analyses were used for voxel-wise group comparison of fractional anisotropy (FA), a sensitive measure of white matter integrity. DNA methylation analyses of umbilical cord tissue focused on genes known to be important in CNS development were also performed.
resultsNewborns from obese women had significantly lower FA values in multiple white matter regions than those born of normal-weight mothers. Global and regional FA values negatively correlated (P < 0.05) with maternal fat mass percentage. Linear regression analysis followed by gene ontology enrichment showed that methylation status of 68 CpG sites representing 57 genes with GO terms related to CNS development was significantly associated with maternal adiposity status.
conclusionsThese results suggest a negative association between maternal adiposity and white matter development in offspring.
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