ArticleThe Journal of pediatrics2015
Neonatal sepsis 2004-2013: the rise and fall of coagulase-negative staphylococci.
Article in The Journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- Impact of neonatal sepsis on neurocognitive outcomes: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Antibiotic regimens for late-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021Pooled it
- Randomized Controlled Trial of Talactoferrin Oral Solution in Preterm Infants.The Journal of pediatrics · 2016Trial
- Infection or contamination - Clinical attribution of blood culture-positive episodes in neonatal intensive care: an 11-year retrospective single-center study.BMC infectious diseases · 2026Article
- Sepsis and Antibiotics in Extremely Preterm Infants: Early Empirical Treatment Was Common, While Late-Onset Sepsis Accounted for Most Cases and Antibiotic Use.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Vancomycin Therapeutic Drug Monitoring, Clinical Outcomes and Population Pharmacokinetic Model Evaluation in Neonates.Children (Basel, Switzerland) · 2026Article
- Factors associated with persistent bloodstream infection in the Neonatal Intensive Care Unit.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- A Review of Probiotic Interventions for Necrotizing Enterocolitis and Sepsis in Preterm Infants.International journal of molecular sciences · 2026Review
- Coagulase-Negative Staphylococci (CoNS): An Emerging Threat, Antimicrobial Resistance, and Health Concern.International journal of microbiology · 2026Review
- Evaluation of antibiotic consumption and resistance patterns among neonates: a 10-year retrospective study.Frontiers in pediatrics · 2026Article
- Serial physical examination to reduce unnecessary antibiotic exposure in newborn infants: a population-based study.Archives of disease in childhood. Fetal and neonatal edition · 2025Article
- Epidemiology of bacterial and fungal infections among level IV neonatal units in North America.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Article
- Emergence of multidrug-resistantEmerging microbes & infections · 2024Article
- Article
- Late-onset sepsis in very preterm infants in Norway in 2009-2018: a population-based study.Archives of disease in childhood. Fetal and neonatal edition · 2023Article
- The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies.Antibiotics (Basel, Switzerland) · 2023Review
- Late-Onset Sepsis Mortality among Preterm Infants: Beyond Time to First Antibiotics.Microorganisms · 2023Article
- Determinants of morbidity and mortality related to health care-associated primary bloodstream infections in neonatal intensive care units: a prospective cohort study from the SEPREVEN trial.Frontiers in pediatrics · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate data for the period 2004-2013 to identify changes in demographics, pathogens, and outcomes in a single, level IV neonatal intensive care unit. STUDY
designSepsis episodes were identified prospectively and additional information obtained retrospectively from infants with sepsis while in the neonatal intensive care unit from 2004 to 2013. Demographics, hospital course, and outcome data were collected and analyzed. Sepsis was categorized as early (≤3 days of life) or late-onset (>3 days of life).
resultsFour hundred fifty-two organisms were identified from 410 episodes of sepsis in 340 infants. Ninety percent of cases were late-onset. Rates of early-onset sepsis remained relatively static throughout the study period (0.9 per 1000 live births). For the first time in decades, most (60%) infants with early-onset sepsis were very low birth weight and Escherichia coli (45%) replaced group B streptococcus (36%) as the most common organism associated with early-onset sepsis. Rates of late-onset sepsis, particularly due to coagulase-negative staphylococci, decreased significantly after implementation of several infection-prevention initiatives. Coagulase-negative staphylococci were responsible for 31% of all cases from 2004 to 2009 but accounted for no cases of late-onset sepsis after 2011.
conclusionsThe epidemiology and microbiology of early- and late-onset sepsis continue to change, impacted by targeted infection prevention efforts. We believe the decrease in sepsis indicates that these interventions have been successful, but additional surveillance and strategies based on evolving trends are necessary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.