ArticleThe Journal of nervous and mental disease2015
North American Prodrome Longitudinal Study (NAPLS 2): The Prodromal Symptoms.
Article in The Journal of nervous and mental disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03932136 (Decreasing Risk of Psychosis by Sulforaphane), which is not on this map. Cited by 147 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Decreasing Risk of Psychosis by Sulforaphane: Study Protocol for a Randomized, Double-blind, Placebo-controlled, Clinical Multicenter Trial (DROPS Trial)
Who cites it
147 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis.Molecular psychiatry · 2024Pooled it
- The association between migrant status and transition in an ultra-high risk for psychosis population.Social psychiatry and psychiatric epidemiology · 2021Pooled it
- Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A Meta-Analysis.Frontiers in psychiatry · 2020Pooled it
- Negative Symptoms and Functioning in Youth at Risk of Psychosis: A Systematic Review and Meta-analysis.Harvard review of psychiatryPooled it
- Family-focused therapy for individuals at high clinical risk for psychosis: A confirmatory efficacy trial.Early intervention in psychiatry · 2022Trial
- Social work training to reduce duration of untreated psychosis: Methodology and considerations of a web-based training for community providers.Early intervention in psychiatry · 2022Trial
- Computer-aided learning for managing stress: A feasibility trial with clinical high risk adolescents and young adults.Early intervention in psychiatry · 2021Trial
- Intensive Auditory Cognitive Training Improves Verbal Memory in Adolescents and Young Adults at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2016Trial
- Visual P300 and Risk for Psychosis Onset in Youth at Clinical High Risk.Biological psychiatry · 2026Article
- Measuring Social and Role Recovery: Barbara Cornblatt and Colleagues' Global Functioning Scales and Their Role in Psychosocial Interventions for Clinical High-Risk and Early Psychosis.Schizophrenia bulletin · 2026Article
- Social withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability.Schizophrenia research · 2026Article
- Development and Validation of a Cross-Dimensional Screening Protocol for Remote Phenotyping Applied to Individuals With 3q29 Deletion Syndrome.Journal of intellectual disability research : JIDR · 2026Article
- Correlation networks of blood proteins in the neuroimmunology of schizophrenia-replication and extension.Translational psychiatry · 2026Article
- Social Determinants and Mental Health Care Utilization Among Individuals at Clinical High Risk for Psychosis.Psychiatric services (Washington, D.C.) · 2026Article
- Exploring the Pathways Between Early Auditory Processing, Processing Speed, Social Cognition, and Negative Symptoms on Social Functioning in Individuals at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach.Biological psychiatry · 2026Article
- Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity.Biological psychiatry global open science · 2026Article
- Functional network comparative area and topography analysis (FUNCATA) in non-affective psychosis: a replication study.Schizophrenia (Heidelberg, Germany) · 2026Article
- Latent profile analysis of delusion-like experiences among emerging adults of Kashmir.BMC psychology · 2026Article
- Structural and Functional Neuroimaging Biomarkers as Predictors of Psychosis Conversion in Ultra-High Risk Individuals: A Systematic Review.Brain sciences · 2026Review
- Predicting ordinal clinical outcomes in at-risk mental states: a multimodal approach.Frontiers in psychiatry · 2026Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
In studies describing the long-term follow-up up of youth at clinical high risk (CHR) of psychosis, little attention has been given to details of specific prodromal symptoms. In this paper, we describe the prodromal symptoms of 764 CHR participants recruited in the multi-site North American Prodrome Longitudinal Study (NAPLS). Symptoms were rated on the Scale of Prodromal Symptoms (SOPS) at baseline and 6-, 12-, 18-, and 24-month follow-ups. Clinical outcome at the 2-year assessment was categorized as psychotic, prodromal progression, symptomatic or in remission. Most of the CHR sample (92%) met criteria for the attenuated positive symptoms syndrome (APSS). Significant improvements in SOPS symptoms were observed over time. Unusual thought content, disorganized communication, and overall ratings on disorganized symptoms differentiated those who transitioned to psychosis from the other clinical outcome groups. Suspiciousness and total positive symptoms differentiated those in remission from the other clinical outcome groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.