Evidence map›Paper›PMID 25919124›Full record

ArticlePloS one2015

Multilocus Sequence Typing of Pathogenic Candida albicans Isolates Collected from a Teaching Hospital in Shanghai, China: A Molecular Epidemiology Study.

Kefei Wu, Tao Luo, Li Li, Qiangqiang Zhang, Junhao Zhu, Qian Gao, Min Chen, Min Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Multilocus sequence typing ofOne health (Amsterdam, Netherlands) · 2025
    Article
  2. Article
  3. Diversity of the diploid sequence type ofNew microbes and new infections · 2020
    Article
  4. Article
  5. A Predominance of Clade 17Frontiers in microbiology · 2019
    Article
  6. Article
  7. Diversity analysis ofFood science and biotechnology · 2018
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kefei WuThe Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China; Key Laboratory of Medical Molecular Virology, Institutes of Biomedical Sciences and Institute of Medical Microbiology, Fudan University, Shanghai, 200032, People's Republic of China.
Tao LuoKey Laboratory of Medical Molecular Virology, Institutes of Biomedical Sciences and Institute of Medical Microbiology, Fudan University, Shanghai, 200032, People's Republic of China.
Li LiThe Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.
Qiangqiang ZhangThe Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.
Junhao ZhuThe Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.
Qian GaoKey Laboratory of Medical Molecular Virology, Institutes of Biomedical Sciences and Institute of Medical Microbiology, Fudan University, Shanghai, 200032, People's Republic of China.
Min ChenShanghai Key Laboratory of Molecular Medical Mycology, Department of Dermatology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
Min ZhuThe Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular typing of Candida albicans is important for studying the population structure and epidemiology of this opportunistic yeast, such as population dynamics, nosocomial infections, multiple infections and microevolution. The genetic diversity of C. albicans has been rarely studied in China. In the present study, multilocus sequence typing (MLST) was used to characterize the genetic diversity and population structure of 62 C. albicans isolates collected from 40 patients from Huashan Hospital in Shanghai, China. A total of 50 diploid sequence types (DSTs) were identified in the 62 C. albicans isolates, with 41 newly identified DSTs. Based on cluster analysis, the 62 isolates were classified into nine existing clades and two new clades (namely clades New 1 and New 2). The majority of the isolates were clustered into three clades, clade 6 (37.5%), clade 1 (15.0%) and clade 17 (15.0%). Isolates of clade New 2 were specifically identified in East Asia. We identified three cases of potential nosocomial transmission based on association analysis between patients' clinical data and the genotypes of corresponding isolates. Finally, by analyzing the genotypes of serial isolates we further demonstrated that the microevolution of C. albicans was due to loss of heterozygosity. Our study represents the first molecular typing of C. albicans in eastern China, and we confirmed that MLST is a useful tool for studying the epidemiology and evolution of C. albicans.

Indexed as

Hospitals, TeachingCandida albicansChinaCross InfectionDiploidyGenetic MarkersHumansMolecular EpidemiologyMultilocus Sequence TypingMycological Typing TechniquesPolymorphism, GeneticGenetic Markers

Identifiers

PMID25919124
PMCPMC4412568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.