Evidence map›Paper›PMID 25919011›Full record

Trial reportPloS one2014

Are pain-related fears mediators for reducing disability and pain in patients with complex regional pain syndrome type 1? An explorative analysis on pain exposure physical therapy.

Karlijn J Barnhoorn, J Bart Staal, Robert T M van Dongen, Jan Paul M Frölke, Frank P Klomp, Henk van de Meent, Han Samwel, Maria W G Nijhuis-van der Sanden

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00817128 (Pain Exposure Physical Therapy Or Conservative Therapy for Patients With Complex Regional Pain Syndrome Type I), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00817128 phase2 / phase3completednot on this map

Pain Exposure Physical Therapy Or Conservative Therapy for Patients With Complex Regional Pain Syndrome Type I

TypeinterventionalSponsorRadboud University Medical CenterRan2009 to 2012Enrolled62ConditionsComplex Regional Pain Syndrome, Type IArmsPEPT, CBO standard
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Treatment of complex regional pain syndrome.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Karlijn J BarnhoornScientific Institute for Quality of Healthcare, Radboud university medical center, Nijmegen, The Netherlands.
J Bart StaalScientific Institute for Quality of Healthcare, Radboud university medical center, Nijmegen, The Netherlands.
Robert T M van DongenDepartment of Anaesthesiology, Pain and Palliative Care, Radboud university medical center, Nijmegen, The Netherlands.
Jan Paul M FrölkeDepartment of Surgery, Radboud university medical center, Nijmegen, The Netherlands.
Frank P KlompDepartment of Orthopaedics, Section Physical Therapy, Radboud university medical center, Nijmegen, The Netherlands.
Henk van de MeentDepartment of Rehabilitation, Radboud university medical center, Nijmegen, The Netherlands.
Han SamwelDepartment of Medical Psychology, Radboud university medical center, Nijmegen, The Netherlands.
Maria W G Nijhuis-van der SandenScientific Institute for Quality of Healthcare, Radboud university medical center, Nijmegen, The Netherlands; Department of Rehabilitation, Radboud university medical center, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLRadboud University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether pain-related fears are mediators for reducing disability and pain in patients with Complex Regional Pain Syndrome type 1 when treating with Pain Exposure Physical Therapy.

designAn explorative secondary analysis of a randomised controlled trial.

participantsFifty-six patients with Complex Regional Pain Syndrome type 1.

interventionsThe experimental group received Pain Exposure Physical Therapy in a maximum of five treatment sessions; the control group received conventional treatment following the Dutch multidisciplinary guideline. OUTCOME MEASURES: Levels of disability, pain, and pain-related fears (fear-avoidance beliefs, pain catastrophizing, and kinesiophobia) were measured at baseline and after 3, 6, and 9 months follow-up.

resultsThe experimental group had a significantly larger decrease in disability of 7.77 points (95% CI 1.09 to 14.45) and in pain of 1.83 points (95% CI 0.44 to 3.23) over nine months than the control group. The potential mediators pain-related fears decreased significantly in both groups, but there were no significant differences between groups, which indicated that there was no mediation.

conclusionThe reduction of pain-related fears was comparable in both groups. We found no indication that pain-related fears mediate the larger reduction of disability and pain in patients with Complex Regional Pain Syndrome type 1 treated with Pain Exposure Physical Therapy compared to conventional treatment.

trial registrationInternational Clinical Trials Registry NCT00817128.

Indexed as

AdultFearFemaleHumansMaleMiddle AgedPainPain MeasurementReflex Sympathetic DystrophyTreatment Outcome

Identifiers

PMID25919011
PMCPMC4412526
OpenAlexW1995320320

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.