Evidence map›Paper›PMID 25918983›Full record

ArticleThe Journal of investigative dermatology2015

Prognostic Significance of Promoter Hypermethylation and Diminished Gene Expression of SYNPO2 in Melanoma.

Linda Gao, Karin van den Hurk, Jérémie Nsengimana, Jonathan P Laye, Joost J van den Oord, Samuel Beck, Nelleke A Gruis, Willem H Zoutman, Manon van Engeland, Julia A Newton-Bishop and 2 more

Open access · greenAbstract readLetter
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Synaptopodin-2: a potential tumor suppressor.Cancer cell international · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Linda GaoDepartment of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
Karin van den HurkDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
Jérémie NsengimanaSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Jonathan P LayeSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Joost J van den OordLaboratory of Translational Cell and Tissue Research and University Hospitals, University of Leuven, KUL, Leuven, Belgium.
Samuel BeckLeiden Cytology and Pathology Laboratory, Rijswijk, The Netherlands.
Nelleke A GruisDepartment of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
Willem H ZoutmanDepartment of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
Manon van EngelandDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
Julia A Newton-BishopSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Véronique J WinnepenninckxDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
Remco van DoornDepartment of Dermatology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: rvandoorn@lumc.nl.
Leiden University Medical Center · NLMaastricht University · NLUniversity of Leeds · GBKU Leuven · BE

Funding

Cancer Research UK 11963Cancer Research UK 19167Cancer Research UK C588/A19167
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, NeoplasticDNA MethylationDown-RegulationFemaleHumansMaleMelanomaMicrofilament ProteinsPredictive Value of TestsPrognosisPromoter Regions, GeneticSensitivity and SpecificitySkin NeoplasmsSurvival AnalysisMicrofilament ProteinsSYNPO2 protein, human

Identifiers

PMID25918983
OpenAlexW2047038212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.