ArticleAmerican journal of respiratory and critical care medicine2015
Stress and Bronchodilator Response in Children with Asthma.
Open access · greenAbstract readComparative Study
In one paragraph
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
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63citing papers in PubMed, 4 pooled it
5.8field-weighted citation impact, top 3% of its field
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Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Violence-Related Distress, Nasal Epithelial Gene Expression, and T17-High Asthma in Youth.Pediatric pulmonology · 2026Pooled it
- Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.Scientific reports · 2022Pooled it
- Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children.Pediatric pulmonology · 2021Pooled it
- Pharmacogenetic research activity in Central America and the Caribbean: a systematic review.Pharmacogenomics · 2016Pooled it
- Resting state functional connectivity changes following mindfulness-based stress reduction predict improvements in disease control for patients with asthma.Brain, behavior, and immunity · 2024Trial
- Violence-related distress and lung function in two longitudinal studies of youth.The European respiratory journal · 2022Trial
- A Multiomics Approach to Identify Genes Associated with Childhood Asthma Risk and Morbidity.American journal of respiratory cell and molecular biology · 2017Trial
- Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- How the Asthmatic Patients Handle During War?Immunity, inflammation and disease · 2026Observational
- Asthma: Biomedical and Psychobiological Perspectives.Biopsychosocial science and medicine · 2025Review
- Fueling the fire in the lung-brain axis: The salience network connects allergen-provoked TH17 responses to psychological stress in asthma.Brain, behavior, and immunity · 2025Article
- Health Disparities in Pediatric Asthma.Respiratory care · 2025Review
- Psychological stress and its association with bronchial asthma in Saudi Arabia: A cross-sectional study.Saudi medical journal · 2025Article
- The effects of violence and related stress on asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Associations between psychosocial stress, child's anxiety, and lung function in mid-childhood.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Prediction of Asthma Exacerbations in Children.Journal of personalized medicine · 2023Review
- Asthma and Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2023Review
- Management of comorbidities in difficult and severe asthma.Breathe (Sheffield, England) · 2023Review
- Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee.The Journal of allergy and clinical immunology · 2023Article
- Brain-Airway Interactions in Asthma.Advances in experimental medicine and biology · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
47 authors at 18 institutions in 5 countries.
John M Brehm1 Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, and.
Sima K Ramratnam1 Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, and.
Sze Man Tse2 Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Damien C Croteau-Chonka2 Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Maria Pino-Yanes3 Department of Bioengineering and Therapeutic Sciences and.
Christian Rosas-Salazar1 Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, and.
Augusto A Litonjua2 Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Benjamin A Raby2 Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Nadia Boutaoui1 Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, and.
Yueh-Ying Han1 Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, and.
Wei Chen1 Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, and.
Erick Forno1 Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, and.
Anna L Marsland6 Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Nicole R Nugent7 Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island.
Celeste Eng3 Department of Bioengineering and Therapeutic Sciences and.
Angel Colón-Semidey8 Behavioral Sciences Research Institute, University of Puerto Rico, Medical Science Campus, San Juan, Puerto Rico.
María Alvarez8 Behavioral Sciences Research Institute, University of Puerto Rico, Medical Science Campus, San Juan, Puerto Rico.
Edna Acosta-Pérez8 Behavioral Sciences Research Institute, University of Puerto Rico, Medical Science Campus, San Juan, Puerto Rico.
Melissa L Spear3 Department of Bioengineering and Therapeutic Sciences and.
Fernando D Martinez9 Arizona Respiratory Center and BIO5 Institute, University of Arizona, Tucson, Arizona.
Lydiana Avila10 Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica.
Scott T Weiss2 Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Manuel Soto-Quiros10 Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica.
Carole Ober11 Department of Human Genetics, University of Chicago, Chicago, Illinois.
Dan L Nicolae11 Department of Human Genetics, University of Chicago, Chicago, Illinois.
Kathleen C Barnes12 Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Robert F Lemanske13 Department of Pediatrics and.
Robert C Strunk15 Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Andrew Liu16 Department of Pediatrics, National Jewish Health, Denver, Colorado.
Stephanie J London17 National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina.
Frank Gilliland18 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Patrick Sleiman19 The Center for Applied Genomics, The Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania.
Michael March19 The Center for Applied Genomics, The Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania.
Hakon Hakonarson19 The Center for Applied Genomics, The Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania.
Qing Ling Duan2 Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Jay K Kolls1 Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, and.
Gregory K Fritz7 Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island.
Donglei Hu3 Department of Bioengineering and Therapeutic Sciences and.
Negar Fani21 Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia; and.
Jennifer S Stevens21 Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia; and.
Lynn M Almli21 Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia; and.
Esteban G Burchard3 Department of Bioengineering and Therapeutic Sciences and.
Jaemin Shin22 Center for Advanced Brain Imaging, Georgia Institute of Technology and Georgia State University, Atlanta, Georgia.
Elizabeth L McQuaid7 Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island.
Kerry Ressler21 Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia; and.
Glorisa Canino8 Behavioral Sciences Research Institute, University of Puerto Rico, Medical Science Campus, San Juan, Puerto Rico.
Juan C Celedón1 Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, and.
Children's Hospital of Pittsburgh · USBrigham and Women's Hospital · USUniversity of California, San Francisco · USEmory University · USUniversity of Puerto Rico, Medical Sciences Campus · PRBrown University · USChildren's Hospital of Philadelphia · USHospital Nacional de Niños · CRUniversity of Chicago · USGeorgia Institute of Technology · USJohns Hopkins University · USNational Institutes of Health · USNational Jewish Health · USUniversity of Arizona · USUniversity of Pittsburgh · USUniversity of Southern California · USUniversity of Wisconsin–Madison · USWashington University in St. Louis · US
Funding
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8MTranslational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4MTHE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5MTranslational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3MZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0MNew Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1MZOSUQUIDAR TRIHYDROCHLORIDE IN NEWLY DIAGNOSED AMLM01RR003186 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MATLOUB, YOUSIF H · 1986 to 2007
$19.3MThe Genetic Epidemiology of Asthma in Costa RicaR37HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2015
$14.6MSYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6MStatistical GeneticsP01HL083069 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2011
$12.2MThe Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MCLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9MNCATS NIH HHS UL1 TR000005NCRR NIH HHS M01 RR000079NCRR NIH HHS M01 RR00079NCRR NIH HHS M01 RR003186NCRR NIH HHS M01 RR0318NHLBI NIH HHS HL04370NHLBI NIH HHS HL066289NHLBI NIH HHS HL073373NHLBI NIH HHS HL079966NHLBI NIH HHS HL117004NHLBI NIH HHS HL117191NHLBI NIH HHS K01 HL004370NHLBI NIH HHS K23 HL004464NHLBI NIH HHS P01 HL083069NHLBI NIH HHS P01HL083069NHLBI NIH HHS R01-HL004464NHLBI NIH HHS R01 HL066289NHLBI NIH HHS R01 HL073373NHLBI NIH HHS R01 HL078885NHLBI NIH HHS R01-HL078885NHLBI NIH HHS R01 HL079966NHLBI NIH HHS R01 HL086601NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01-HL088133NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01-HL104608NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117191NHLBI NIH HHS R37 HL066289NHLBI NIH HHS T32 HL007427NHLBI NIH HHS U01 HL065899NHLBI NIH HHS U01 HL 072438NHLBI NIH HHS U01 HL072438NHLBI NIH HHS U01 HL075419NHLBI NIH HHS U01 HL51510NHLBI NIH HHS U01 HL51831NHLBI NIH HHS U01HL51834NHLBI NIH HHS U01 HL51843NHLBI NIH HHS U01 HL51845NHLBI NIH HHS U01 HL65899NHLBI NIH HHS U10 HL051831NHLBI NIH HHS U10 HL051834NHLBI NIH HHS U10 HL051843NHLBI NIH HHS U10 HL051845NICHD NIH HHS HD052892NICHD NIH HHS K12 HD052892NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R01-ES015794NIGMS NIH HHS T32 GM007546NIGMS NIH HHS T32-GM007546NIMHD NIH HHS P60 MD006902NIMHD NIH HHS P60MD006902NIMH NIH HHS F32 MH101976
Abstract
rationaleStress is associated with asthma morbidity in Puerto Ricans (PRs), who have reduced bronchodilator response (BDR).
objectivesTo examine whether stress and/or a gene regulating anxiety (ADCYAP1R1) is associated with BDR in PR and non-PR children with asthma.
methodsThis was a cross-sectional study of stress and BDR (percent change in FEV1 after BD) in 234 PRs ages 9-14 years with asthma. We assessed child stress using the Checklist of Children's Distress Symptoms, and maternal stress using the Perceived Stress Scale. Replication analyses were conducted in two cohorts. Polymorphisms in ADCYAP1R1 were genotyped in our study and six replication studies. Multivariable models of stress and BDR were adjusted for age, sex, income, environmental tobacco smoke, and use of inhaled corticosteroids. MEASUREMENTS AND MAIN
resultsHigh child stress was associated with reduced BDR in three cohorts. PR children who were highly stressed (upper quartile, Checklist of Children's Distress Symptoms) and whose mothers had high stress (upper quartile, Perceived Stress Scale) had a BDR that was 10.2% (95% confidence interval, 6.1-14.2%) lower than children who had neither high stress nor a highly stressed mother. A polymorphism in ADCYAP1R1 (rs34548976) was associated with reduced BDR. This single-nucleotide polymorphism is associated with reduced expression of the gene for the β2-adrenergic receptor (ADRB2) in CD4(+) lymphocytes of subjects with asthma, and it affects brain connectivity of the amygdala and the insula (a biomarker of anxiety).
conclusionsHigh child stress and an ADCYAP1R1 single-nucleotide polymorphism are associated with reduced BDR in children with asthma. This is likely caused by down-regulation of ADRB2 in highly stressed children.
Indexed as
AdolescentAnxietyAsthmaBronchodilator AgentsCase-Control StudiesChildCross-Sectional StudiesDown-RegulationFemaleGenetic MarkersGenotypeHumansLinear ModelsMaleMultivariate AnalysisPolymorphism, Single NucleotideADCYAP1R1 protein, humanADRB2 protein, humanBronchodilator AgentsGenetic MarkersReceptors, Adrenergic, beta-2Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type Iasthmabronchodilator responsePuerto Ricansstress
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