ReviewJournal of diabetes research2015
Cardiovascular control during exercise in type 2 diabetes mellitus.
Review in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03256747 (Effects of Neuromuscular Electrical Stimulation on Glucose Levels and Glucose Variability in Patients With Type 2 Diabetes), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Neuromuscular Electrical Stimulation on Glucose Levels and Glucose Variability in Patients With Type 2 Diabetes: a Randomized Clinical Trial
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Effects of pioglitazone with and without exercise training on cardiorespiratory fitness and oxygen uptake kinetics in type 2 diabetes.Diabetes, obesity & metabolism · 2025Trial
- Exercise training improves cardiorespiratory fitness and oxygen uptake kinetics to a similar extent in early and late middle-aged adults with type 2 diabetes.Physiological reports · 2026Article
- Associations Between Triglycerides and Walking Capacity in Community-Dwelling Older Adults with Metabolic Syndrome.Diseases (Basel, Switzerland) · 2026Article
- Effect of slow deep breathing on cardiovascular autonomic neuropathy in type 2 diabetes mellitus patients.Diabetology & metabolic syndrome · 2025Article
- Muscle deoxygenation during ramp incremental cycle exercise in older adults with type 2 diabetes.European journal of applied physiology · 2024Article
- Factors Affecting Recovery of 6-Minute Walk Distance After Coronary Artery Bypass Grafting.Circulation reports · 2023Article
- How Priming Exercise Affects Oxygen Uptake Kinetics: From Underpinning Mechanisms to Endurance Performance.Sports medicine (Auckland, N.Z.) · 2023Review
- Prolonged mean response time in older adults with cardiovascular risk compared to healthy older adults.BMC sports science, medicine & rehabilitation · 2022Article
- Impaired functional exercise capacity and greater cardiovascular response to the 6-min walk test in congenital generalized lipodystrophy.BMC cardiovascular disorders · 2022Article
- Analysis of Blood Pressure and Ventilation Efficiency in Different Types of Obesity Aged 40-60 Years by Cardiopulmonary Exercise Test.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- A Correlational Study on Cardiopulmonary Endurance in Male Patients with New-Onset Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Priming exercise accelerates oxygen uptake kinetics during high-intensity cycle exercise in middle-aged individuals with type 2 diabetes.Frontiers in physiology · 2022Article
- Priming exercise accelerates pulmonary oxygen uptake kinetics during "work-to-work" cycle exercise in middle-aged individuals with type 2 diabetes.European journal of applied physiology · 2021Article
- Neurovascular Dysregulation During Exercise in Type 2 Diabetes.Frontiers in physiology · 2021Review
- Increased Cardiovascular Response to a 6-Minute Walk Test in People With Type 2 Diabetes.Diabetes spectrum : a publication of the American Diabetes Association · 2020Article
- Gender Differences in Aggression-related Responses on EEG and ECG.Experimental neurobiology · 2018Article
- Article
- Effect of obesity on oxygen uptake and cardiovascular dynamics during whole-body and leg exercise in adult males and females.Physiological reports · 2018Article
- Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes.Cardiovascular diabetology · 2017Article
- The Type 2 Diabetic Heart: Its Role in Exercise Intolerance and the Challenge to Find Effective Exercise Interventions.Sports medicine (Auckland, N.Z.) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
Controlled studies of male and female subjects with type 2 diabetes mellitus (DM) of short duration (~3-5 years) show that DM reduces peak VO2 (L·min(-1) and mL·kg(-1)·min(-1)) by an average of 12-15% and induces a greater slowing of the dynamic response of pulmonary VO2 during submaximal exercise. These effects occur in individuals less than 60 years of age but are reduced or absent in older males and are consistently associated with significant increases in the exercise pressor response despite normal resting blood pressure. This exaggerated pressor response, evidence of exertional hypertension in DM, is manifest during moderate submaximal exercise and coincides with a more constrained vasodilation in contracting muscles. Maximum vasodilation during contractions involving single muscle groups is reduced by DM, and the dynamic response of vasodilation during submaximal contractions is slowed. Such vascular constraint most likely contributes to exertional hypertension, impairs dynamic and peak VO2 responses, and reduces exercise tolerance. There is a need to establish the effect of DM on dynamic aspects of vascular control in skeletal muscle during whole-body exercise and to clarify contributions of altered cardiovascular control and increased arterial stiffness to exertional hypertension.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.