ArticleGastroenterology research and practice2015
Increased chromogranin a cell density in the large intestine of patients with irritable bowel syndrome after receiving dietary guidance.
Article in Gastroenterology research and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Efficacy of diet restriction with or without probiotic for treatment of patients with IBS-D: Phase I-II clinical trial.Immunity, inflammation and disease · 2023Trial
- Chromogranin A as a Novel Biomarker of Irritable Bowel Syndrome in Adults: A Systematic Review and Meta-Analysis.Middle East journal of digestive diseases · 2025Review
- Article
- Global Research Trends in Irritable Bowel Syndrome: A Bibliometric and Visualized Study.Frontiers in medicine · 2022Article
- Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.EMBO molecular medicine · 2021Article
- The role of diet in the pathophysiology and management of irritable bowel syndrome.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Review
- Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome.World journal of gastroenterology · 2020Review
- Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy.Frontiers in immunology · 2020Review
- Diet in Irritable Bowel Syndrome (IBS): Interaction with Gut Microbiota and Gut Hormones.Nutrients · 2019Review
- Effect of diet and individual dietary guidance on gastrointestinal endocrine cells in patients with irritable bowel syndrome (Review).International journal of molecular medicine · 2017Review
- Dietary fiber in irritable bowel syndrome (Review).International journal of molecular medicine · 2017Article
- Changes in duodenal enteroendocrine cells in patients with irritable bowel syndrome following dietary guidance.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Deciphering the pathophysiology of irritable bowel syndrome and functional gastrointestinal disorders-an alternative model for pathogenesis: cytokine controlled transepithelial multi-feedback loop.Translational gastroenterology and hepatology · 2017Review
- Dietary guidance and ileal enteroendocrine cells in patients with irritable bowel syndrome.Experimental and therapeutic medicine · 2016Article
- Interaction between diet and gastrointestinal endocrine cells.Biomedical reports · 2016Article
- Changes in small intestinal chromogranin A-immunoreactive cell densities in patients with irritable bowel syndrome after receiving dietary guidance.International journal of molecular medicine · 2016Article
- Dietary guidance normalizes large intestinal endocrine cell densities in patients with irritable bowel syndrome.European journal of clinical nutrition · 2016Article
- Recent developments in the pathophysiology of irritable bowel syndrome.World journal of gastroenterology · 2015Review
- Diet in irritable bowel syndrome.Nutrition journal · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The large intestine contains five types of endocrine cells that regulate its functions by sensing its luminal contents and releasing specific hormones. Chromogranin A (CgA) is a common marker for the gastrointestinal endocrine cells, and it is abnormal in irritable bowel syndrome (IBS) patients. Most IBS patients relate their symptoms to certain food elements. The present study investigated the effect of dietary guidance on the total endocrine cells of the large intestine as detected by CgA in 13 IBS patients. Thirteen control subjects were also included. Each patient received three sessions of dietary guidance. Colonoscopies were performed on controls and patients (at baseline and at 3-9 months after receiving guidance). Biopsy samples from the colon and rectum were immunostained for CgA and quantified by computerized image analysis. The densities of CgA cells in the total colon (mean ± SEM) among the controls and the IBS patients before and after receiving dietary guidance were 83.3 ± 10.1, 38.6 ± 3.7, and 64.7 ± 4.2 cells/mm(2), respectively (P = 0.0004), and were unchanged in the rectum. In conclusion, the increase in CgA cell density after receiving dietary guidance may reflect a change in the densities of the large intestinal endocrine cells causing an improvement in the IBS symptoms.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.