ArticleMediators of inflammation2015
Gender-specific association of oxidative stress and inflammation with cardiovascular risk factors in Arab population.
Article in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
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- Circulating IL-6, clusterin and irisin in obese subjects with different grades of obesity: association with insulin resistance and sexual dimorphism.Archives of endocrinology and metabolism · 2021Article
- Sex dimorphism in inflammatory response to obesity in childhood.International journal of obesity (2005) · 2021Article
- Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population.Neuropsychiatric disease and treatment · 2020Article
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- Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population.Neuropsychiatric disease and treatment · 2020Article
- Sexual Dimorphism in Cardiovascular Disease Risk and Risk Factors Among Vegetarians: an Exploration of the Potential Mechanisms.Current atherosclerosis reports · 2019Review
- Association between vitamin D and risk of cardiovascular disease in Chinese rural population.PloS one · 2019Article
- DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases.Disease markers · 2018Article
- Obesity moderates the complex relationships between inflammation, oxidative stress, sleep quality and depressive symptoms.BMC obesity · 2018Article
- Prenatal phthalate exposure and 8-isoprostane among Mexican-American children with high prevalence of obesity.Journal of developmental origins of health and disease · 2017Article
- Genetic, Immune-Inflammatory, and Oxidative Stress Biomarkers as Predictors for Disability and Disease Progression in Multiple Sclerosis.Molecular neurobiology · 2017Article
- Elevated plasma F2-isoprostane levels in schizophrenia.Schizophrenia research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of gender difference on the association between metabolic stress and cardiovascular disease (CVD) remains unclear. We have investigated, for the first time, the gender effect on the oxidative and inflammatory stress responses and assessed their correlation with classical cardiometabolites in Arab population.
methodsA total of 378 adult Arab participants (193 females) were enrolled in this cross-sectional study. Plasma levels of CRP, IL-6, IL-8, TNF-α, ROS, TBARs, and PON1 were measured and correlated with anthropometric and cardiometabolite parameters of the study population.
resultsCompared to females, males had significantly higher FBG, HbA1c, TG, and blood pressure but lower BMI, TC, and HDL (P < 0.05). After adjustment for BMI and WC, females had higher levels of ROS, TBARS, and CRP (P < 0.001) whereas males had increased levels of IL-8, IL-6, and TNF-α (P < 0.05). Moreover, after adjustment for age, BMI, and gender, the levels of TNF-α, IL-6, and ROS were associated with central obesity but not general obesity.
conclusionInflammation and oxidative stress contribution to CVD risk in Arab population linked to gender and this risk is better reflected by central obesity. Arab females might be at risk of CVD complications due to increased oxidative stress.
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