ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Carriage burden, multiple colonization and antibiotic pressure promote emergence of resistant vaccine escape pneumococci.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Genomic and statistical models to characterizeMicrobial genomics · 2026Article
- Article
- Epidemiological analysis of respiratory pathogen detection in 11 regions of Yunnan from 2021 to 2023.Frontiers in public health · 2026Article
- A pathogen peptidoglycan scaffold coated with artificial biomembrane promotes broad resistance to bacterial infections by dynamically reprogramming macrophage metabolism.Materials today. Bio · 2025Article
- Assessing the risk of vaccine-driven virulence evolution in SARS-CoV-2.Royal Society open science · 2022Article
- Efficacy of a Protein Vaccine and a Conjugate Vaccine Against Co-colonization with Vaccine-type and Non-vaccine Type Pneumococci in Mice.Pathogens (Basel, Switzerland) · 2020Article
- Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Application of dynamic modelling techniques to the problem of antibacterial use and resistance: a scoping review.Epidemiology and infection · 2018Article
- Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae.Biochemistry · 2018Article
- Vaccination can drive an increase in frequencies of antibiotic resistance among nonvaccine serotypes ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Geographic variation in pneumococcal vaccine efficacy estimated from dynamic modeling of epidemiological data post-PCV7.Scientific reports · 2017Article
- Structure-Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for Intra-group and Cross-group ComD Receptor Activation.ACS chemical biology · 2017Article
- The Ongoing Genetic Adaptation of Streptococcus pneumoniae.Journal of clinical microbiology · 2017Article
- Review
- Long-term effects of penicillin resistance and fitness cost on pneumococcal transmission dynamics in a developed setting.Infection ecology & epidemiology · 2016Article
- Interim results of an ecological experiment - Conjugate vaccination against the pneumococcus and serotype replacement.Human vaccines & immunotherapeutics · 2016Review
- Pneumococcal Infection among Children before Introduction of 13-Valent Pneumococcal Conjugate Vaccine, Cambodia.Emerging infectious diseases · 2015Article
- Antimicrobial resistance: addressing the threat to global health. Preface.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
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3 authors.
Funding
Abstract
Pneumococcal conjugate vaccines target the limited subset of the more than 90 known serotypes of Streptococcus pneumoniae responsible for the greatest burden of pneumococcal disease and antibiotic resistance. Following the introduction of these vaccines, serotypes not targeted were able to expand and resistance became more common within these types. Here we use a stochastic dynamic model of pediatric pneumococcal carriage to evaluate potential influences on the emergence of new resistant lineages following the introduction of a vaccine targeting more common resistant types. Antibiotic pressure was the strongest driver, with no emergence at low levels and universal emergence at high levels. At intermediate levels of antibiotic pressure, higher carriage burden and a greater degree of dual carriage promoted emergence. This may have implications for current plans to introduce childhood pneumococcal vaccination in several high-burden countries.
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