ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Antimicrobial resistance in humans, livestock and the wider environment.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 299 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
299 citing papers in PubMed, 4 syntheses or guidelines pooled it, 666 citations in OpenAlex.
- Epidemiology and antimicrobial resistance of staphylococci other thanFrontiers in veterinary science · 2022Pooled it
- Antimicrobial use in cattle and poultry production on occurrence of multidrug resistantFrontiers in veterinary science · 2022Pooled it
- A Systematic Review on Antimicrobial and Antiparasitic Activity ofBioMed research international · 2022Pooled it
- Systematic review and meta-analysis of integrated studies on antimicrobial resistance genes in Africa-A One Health perspective.Tropical medicine & international health : TM & IH · 2021Pooled it
- High-risk antimicrobial resistance genomic traits in multidrug-resistant Salmonella across China's food chain: projections to 2050.Nature communications · 2026Article
- Urban-Adjacent Soils as a Global Reservoir of Toxigenic and Antimicrobial-ResistantInternational journal of molecular sciences · 2026Article
- The COVID-19 pandemic influenced the temporal dynamics of antimicrobial resistance markers and bacterial community across urban wastewater treatment plants.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Global genomic surveillance ofmBio · 2026Article
- Integrated poultry production as a reservoir ofMicrobial genomics · 2026Article
- Stabilizing features of cefotaximase harbouring plasmids enable persistence in UK livestock.Microbial genomics · 2026Article
- AMR in wild animals and plants: global trends and future priorities in wildlife-associated antimicrobial resistance research.npj antimicrobials and resistance · 2026Article
- Prevalence of antibiotic residues in commercial poultry feed and meat from industrial and backyard poultry in Iquitos, Perú.IJID one health · 2026Article
- Effects of conventional and raised without antibiotic feeding systems and exposure to infectious bursal disease virus on microbial diversity of the jejunal microbiota in broiler chickens.Poultry science · 2026Article
- A global analysis of the inclusion of wildlife in national action plans for antimicrobial resistance.JAC-antimicrobial resistance · 2026Article
- Prevalence and risk factors of antimicrobial resistance inOne health (Amsterdam, Netherlands) · 2026Article
- The missing thread of One Health efforts: improper drug disposal as an overlooked driver of antimicrobial resistance.mSphere · 2026Review
- Primary caregivers' practices and perceptions on antibiotic use and resistance: a one health qualitative study in rural South India.BMJ open · 2026Article
- Mobile Genetic Elements Associated with Antimicrobial Resistance Across One Health Interfaces in Africa: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2026Review
- Prevalence and Antimicrobial Resistance ofVeterinary sciences · 2026Article
- Article
239 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Antimicrobial resistance (AMR) in humans is inter-linked with AMR in other populations, especially farm animals, and in the wider environment. The relatively few bacterial species that cause disease in humans, and are the targets of antibiotic treatment, constitute a tiny subset of the overall diversity of bacteria that includes the gut microbiota and vast numbers in the soil. However, resistance can pass between these different populations; and homologous resistance genes have been found in pathogens, normal flora and soil bacteria. Farm animals are an important component of this complex system: they are exposed to enormous quantities of antibiotics (despite attempts at reduction) and act as another reservoir of resistance genes. Whole genome sequencing is revealing and beginning to quantify the two-way traffic of AMR bacteria between the farm and the clinic. Surveillance of bacterial disease, drug usage and resistance in livestock is still relatively poor, though improving, but achieving better antimicrobial stewardship on the farm is challenging: antibiotics are an integral part of industrial agriculture and there are very few alternatives. Human production and use of antibiotics either on the farm or in the clinic is but a recent addition to the natural and ancient process of antibiotic production and resistance evolution that occurs on a global scale in the soil. Viewed in this way, AMR is somewhat analogous to climate change, and that suggests that an intergovernmental panel, akin to the Intergovernmental Panel on Climate Change, could be an appropriate vehicle to actively address the problem.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.