Evidence map›Paper›PMID 25918438›Full record

ReviewReproduction (Cambridge, England)2015

Ovarian cancer: involvement of the matrix metalloproteinases.

Linah Al-Alem, Thomas E Curry

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproduction (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 5 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Linah Al-AlemDepartment of Obstetrics and GynecologyUniversity of Kentucky Medical Center, 800 Rose Street, Room C355, Lexington, Kentucky 40536-0293, USA.
Thomas E CurryDepartment of Obstetrics and GynecologyUniversity of Kentucky Medical Center, 800 Rose Street, Room C355, Lexington, Kentucky 40536-0293, USA tecurry@uky.edu.
University of Kentucky · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Ovulation and Luteal Formation in Rodents Monkeys and WomenP01HD071875 · NICHD · UNIVERSITY OF KENTUCKY · PI CURRY, THOMAS E · 2014 to 2018
$6.1M
The MMP system in human ovulation: localization, regulation, and functionR01HD057446 · NICHD · UNIVERSITY OF KENTUCKY · PI CURRY, THOMAS E · 2009 to 2013
$1.4M
The Role Of CCL20 In Ovulation: A Novel Mediator Of Ovarian Leukocyte RecruitmentR03HD071291 · NICHD · UNIVERSITY OF KENTUCKY · PI CURRY, THOMAS E · 2012 to 2013
$145k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1TR000117NICHD NIH HHS HD057446NICHD NIH HHS P01 HD071875NICHD NIH HHS P01HD071875NICHD NIH HHS R01 HD057446NICHD NIH HHS R03 HD071291NICHD NIH HHS R03HD071291
6 · The paper itself

Abstract

Ovarian cancer is the leading cause of death from gynecologic malignancies. One of the reasons for the high mortality rate associated with ovarian cancer is its late diagnosis, which often occurs after the cancer has metastasized throughout the peritoneal cavity. Cancer metastasis is facilitated by the remodeling of the extracellular tumor matrix by a family of proteolytic enzymes known as the matrix metalloproteinases (MMPs). There are 23 members of the MMP family, many of which have been reported to be associated with ovarian cancer. In the current paradigm, ovarian tumor cells and the surrounding stromal cells stimulate the synthesis and/or activation of various MMPs to aid in tumor growth, invasion, and eventual metastasis. The present review sheds light on the different MMPs in the various types of ovarian cancer and on their impact on the progression of this gynecologic malignancy.

Indexed as

AnimalsFemaleHumansMatrix MetalloproteinasesNeoplasm MetastasisOvarian NeoplasmsMatrix Metalloproteinases

Identifiers

PMID25918438
PMCPMC4955511
OpenAlexW2163519496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.