ArticleProceedings of the National Academy of Sciences of the United States of America2015
Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed.
- Desiccation tolerance mechanisms in the green lineage and beyond.The New phytologist · 2026Review
- Evolutionary insights into an ancient fungal transition from land to sea.bioRxiv : the preprint server for biology · 2026Article
- Anhydrobiosis as a Model of Aging and Longevity: The Role of Autophagy and Metabolism in Yeast Cells.Microbial ecology · 2026Review
- Osmotic signaling governs sunscreen biosynthesis to safeguard desert cyanobacteria against desiccation.mLife · 2026Article
- Exploring the Habitability of the Outer Solar System Icy Moons for the Extremotolerant Yeast Rhodotorula frigidalcoholis.Environmental microbiology · 2026Article
- Drying parameters and aging modulate protective properties of vitrified trehalose.bioRxiv : the preprint server for biology · 2026Article
- Research progress on heat stress response mechanisms inFrontiers in microbiology · 2026Review
- Exogenous KFrontiers in microbiology · 2026Article
- Drying parameters and aging modulate protective properties of vitrified trehalose.BBA advances · 2026Article
- Mycelial dynamics in arbuscular mycorrhizal fungi.The New phytologist · 2026Review
- Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance.Nature communications · 2025Article
- Microbial Biofertilizers for Salinity Stress Mitigation in Hydroponic Systems.Current issues in molecular biology · 2025Review
- Article
- Biomolecular condensates-Prerequisites for anhydrobiosis?Protein science : a publication of the Protein Society · 2025Review
- Molecular Mechanisms ofPlants (Basel, Switzerland) · 2025Review
- Peroxiredoxin Tsa1 Regulates the Activity of Trehalose Metabolism-Related Enzymes During Wine Yeast Biomass Propagation.Microbial biotechnology · 2025Article
- Developing the trehalose biosynthesis pathway as an antifungal drug target.npj antimicrobials and resistance · 2025Review
- Life on the dry side: a roadmap to understanding desiccation tolerance and accelerating translational applications.Nature communications · 2025Review
- Red-light signaling pathway activates desert cyanobacteria to prepare for desiccation tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- LEA_4 motifs function alone and in conjunction with synergistic cosolutes to protect a labile enzyme during desiccation.Protein science : a publication of the Protein Society · 2025Article
33 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
Diverse organisms capable of surviving desiccation, termed anhydrobiotes, include species from bacteria, yeast, plants, and invertebrates. However, most organisms are sensitive to desiccation, likely due to an assortment of different stresses such as protein misfolding and aggregation, hyperosmotic stress, membrane fracturing, and changes in cell volume and shape leading to an overcrowded cytoplasm and metabolic arrest. The exact stress(es) that cause lethality in desiccation-sensitive organisms and how the lethal stresses are mitigated in desiccation-tolerant organisms remain poorly understood. The presence of trehalose in anhydrobiotes has been strongly correlated with desiccation tolerance. In the yeast Saccharomyces cerevisiae, trehalose is essential for survival after long-term desiccation. Here, we establish that the elevation of intracellular trehalose in dividing yeast by its import from the media converts yeast from extreme desiccation sensitivity to a high level of desiccation tolerance. This trehalose-induced tolerance is independent of utilization of trehalose as an energy source, de novo synthesis of other stress effectors, or the metabolic effects of trehalose biosynthetic intermediates, indicating that a chemical property of trehalose is directly responsible for desiccation tolerance. Finally, we demonstrate that elevated intracellular maltose can also make dividing yeast tolerant to short-term desiccation, indicating that other disaccharides have stress effector activity. However, trehalose is much more effective than maltose at conferring tolerance to long-term desiccation. The effectiveness and sufficiency of trehalose as an antagonizer of desiccation-induced damage in yeast emphasizes its potential to confer desiccation tolerance to otherwise sensitive organisms.
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