ArticleThe Journal of experimental medicine2015
Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells.
Article in The Journal of experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative genomics analysis of mononuclear phagocyte subsets confirms homology between lymphoid tissue-resident and dermal XCR1(+) DCs in mouse and human and distinguishes them from Langerhans cells.Journal of immunological methods · 2016Pooled it
- Dendritic cells: the central partner for cancer immunity.Oncoimmunology · 2025Review
- Immunotherapy: A new target for cancer cure (Review).Oncology reports · 2023Review
- CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses.Science (New York, N.Y.) · 2023Article
- Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C-type lectin receptor Langerin.European journal of immunology · 2022Article
- Transcriptional programming of immunoregulatory responses in human Langerhans cells.Frontiers in immunology · 2022Article
- Optimal Isolation Protocols for Examining and Interrogating Mononuclear Phagocytes From Human Intestinal Tissue.Frontiers in immunology · 2021Article
- Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells.Frontiers in immunology · 2021Article
- Genomic programming of IRF4-expressing human Langerhans cells.Nature communications · 2020Article
- Human Tumor-Infiltrating Dendritic Cells: From in Situ Visualization to High-Dimensional Analyses.Cancers · 2019Review
- The Double-Edged Sword-How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer.Frontiers in immunology · 2019Review
- Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection.Frontiers in immunology · 2019Review
- Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria.Science immunology · 2018Article
- Human dendritic cell subsets: an update.Immunology · 2018Review
- Barrier-tissue macrophages: functional adaptation to environmental challenges.Nature medicine · 2017Review
- Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines.Journal of leukocyte biology · 2017Review
- A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease.JCI insight · 2017Article
- Dendritic Cell-Derived IL-32α: A Novel Inhibitory Cytokine of NK Cell Function.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes.Journal of leukocyte biology · 2017Article
- GM-CSF Monocyte-Derived Cells and Langerhans Cells As Part of the Dendritic Cell Family.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characterization of functionally distinct dendritic cell (DC) subsets in mice has fueled interest in whether analogous counterparts exist in humans. Transcriptional modules of coordinately expressed genes were used for defining shared functions between the species. Comparing modules derived from four human skin DC subsets and modules derived from the Immunological Genome Project database for all mouse DC subsets revealed that human Langerhans cells (LCs) and the mouse XCR1(+)CD8α(+)CD103(+) DCs shared the class I-mediated antigen processing and cross-presentation transcriptional modules that were not seen in mouse LCs. Furthermore, human LCs were enriched in a transcriptional signature specific to the blood cross-presenting CD141/BDCA-3(+) DCs, the proposed equivalent to mouse CD8α(+) DCs. Consistent with our analysis, LCs were highly adept at inducing primary CTL responses. Thus, our study suggests that the function of LCs may not be conserved between mouse and human and supports human LCs as an especially relevant therapeutic target.
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