ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2015
Quantifying the risk of Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a case-control study using electronic records.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Cancer risk in patients with recurrent or persistent symptoms: a systematic review.The Lancet regional health. Europe · 2026Review
- Incidence of first and subsequent fractures in multiple myeloma patients: a parallel cohort study using UK CPRD dataset.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- A taxonomy of early diagnosis research to guide study design and funding prioritisation.British journal of cancer · 2023Review
- The effectiveness of the Guy's Rapid Diagnostic Clinic (RDC) in detecting cancer and serious conditions in vague symptom patients.British journal of cancer · 2021Article
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- Role of pretreatment inflammatory indicators in pediatric acute leukemias; where do we stand? A prospective cohort study.Cancer biomarkers : section A of Disease markers · 2020Article
- Hodgkin lymphoma detection and survival: findings from the Haematological Malignancy Research Network.BJGP open · 2019Article
- Predictive value of inflammatory markers for cancer diagnosis in primary care: a prospective cohort study using electronic health records.British journal of cancer · 2019Article
- Disease-related factors affecting timely lymphoma diagnosis: a qualitative study exploring patient experiences.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
- Recognising laryngeal cancer in primary care: a large case-control study using electronic records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
- Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Article
- Symptom Signatures and Diagnostic Timeliness in Cancer Patients: A Review of Current Evidence.Neoplasia (New York, N.Y.) · 2018Review
- Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records.British journal of cancer · 2017Article
- Article
- Risk factors and time to symptomatic presentation in leukaemia, lymphoma and myeloma.British journal of cancer · 2015Article
- Assessing risk and improving survival in lymphoma.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Article
- Quantifying the risk of non-Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a large case-control study using electronic records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Article
- Quantifying the risk of Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a case-control study using electronic records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Article
- Chronic Prurigo: An Unusual Presentation of Hodgkin Lymphoma.Case reports in dermatologyArticle
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Abstract
backgroundIn the UK, approximately five people are diagnosed with Hodgkin lymphoma (HL) daily. One-tenth of diagnoses are in those aged >75 years.
aimTo establish a symptom profile of HL and quantify their risk in primary care patients aged ≥40 years. DESIGN AND
settingMatched case-control study using Clinical Practice Research Datalink patient records.
methodPutative clinical features of HL were identified in the year before diagnosis. Results were analysed using conditional logistic regression and positive predictive values (PPVs) calculated for the consulting population.
resultsTwo-hundred and eighty-three patients aged ≥40 years, diagnosed with HL between 2000 and 2009, and 1237 age, sex, and general practice-matched participants were studied. Six features were independently associated with HL: lymphadenopathy (OR 280, 95% confidence interval [CI] = 25 to 3100), head and neck mass not described as lymphadenopathy (OR 260, 95% CI = 21 to 3200), other mass (OR 12, 95% CI = 4.4 to 35), thrombocytosis (OR 6.0, 95% CI = 2.6 to 14), raised inflammatory markers (OR 5.2, 95% CI = 3.0 to 9.0), and low full blood count (OR 2.8, 95% CI = 1.6 to 4.8). Lymphadenopathy per se has a positive predictive value (PPV) of 5.6% for HL in patients aged ≥60 years.
conclusionConsistent with secondary care findings, lymphadenopathy is the clinical feature with the highest risk of HL in primary care and warrants urgent investigation.
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