ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2015
Quantifying the risk of non-Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a large case-control study using electronic records.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Weight loss as a predictor of cancer in primary care: a systematic review and meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Pooled it
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- Consultations for clinical features of possible cancer and associated urgent referrals before and during the COVID-19 pandemic: an observational cohort study from English primary care.British journal of cancer · 2022Observational
- Microcytosis as a risk marker of cancer in primary care: a cohort study using electronic patient records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Article
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- Role of pretreatment inflammatory indicators in pediatric acute leukemias; where do we stand? A prospective cohort study.Cancer biomarkers : section A of Disease markers · 2020Article
- Predictive value of inflammatory markers for cancer diagnosis in primary care: a prospective cohort study using electronic health records.British journal of cancer · 2019Article
- The determinants and impact of diagnostic delay in lymphoma in a TB and HIV endemic setting.BMC cancer · 2019Article
- Recognising laryngeal cancer in primary care: a large case-control study using electronic records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
- Disease-related factors affecting timely lymphoma diagnosis: a qualitative study exploring patient experiences.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
- Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Article
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- Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records.British journal of cancer · 2017Article
- Medicons: toward clinical examination diagrams standardization in medical documentation.Advances in medical education and practice · 2017Article
- Article
- Affluence and Private Health Insurance Influence Treatment and Survival in Non-Hodgkin's Lymphoma.PloS one · 2016Article
- Risk factors and time to symptomatic presentation in leukaemia, lymphoma and myeloma.British journal of cancer · 2015Article
- Assessing risk and improving survival in lymphoma.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-Hodgkin lymphoma (NHL) is the sixth most common cancer in the UK; approximately 35 people are diagnosed and 13 die from the disease daily.
aimTo identify the primary care clinical features of NHL and quantify their risk in symptomatic patients. DESIGN AND
settingMatched case-control study using Clinical Practice Research Datalink patient records.
methodPutative clinical features of NHL were identified in the year before diagnosis. Results were analysed using conditional logistic regression and positive predictive values (PPVs).
resultsA total of 4362 patients aged ≥40 years, diagnosed with NHL between 2000 and 2009, and 19 468 age, sex, and general practice-matched controls were studied. Twenty features were independently associated with NHL. The five highest risk symptoms were lymphadenopathy, odds ratio (OR) 263 (95% CI = 133 to 519), head and neck mass not described as lymphadenopathy OR 49 (95% CI = 32 to 74), other mass OR 12 (95% CI = 10 to 16), weight loss OR 3.2 (95% CI = 2.3 to 4.4), and abdominal pain OR 2.5 (95% CI = 2.1 to 2.9). Lymphadenopathy has a PPV of 13% for NHL in patients ≥60 years. Weight loss in conjunction with repeated back pain or raised gamma globulin had PPVs >2%.
conclusionUnexplained lymphadenopathy in patients aged ≥60 years produces a very high risk of NHL in primary care. These patients warrant urgent investigation, potentially sooner than 6 weeks from initial presentation where the GP is particularly concerned.
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