Evidence map›Paper›PMID 25918239›Full record

ArticleThe Journal of general virology2015

Discovery of a novel nidovirus in cattle with respiratory disease.

Rafal Tokarz, Stephen Sameroff, Richard A Hesse, Ben M Hause, Aaloki Desai, Komal Jain, W Ian Lipkin

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Evolutionarily divergent nidovirus with an exceptionally large genome identified in Pacific oysters undergoing mass mortality.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Host response to Aplysia Abyssovirus 1 in nervous system and gill.Developmental and comparative immunology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Influence of COVID-19 on the poultry production and environment.Environmental science and pollution research international · 2021
    Review
  12. Review
  13. Nidoviruses in Reptiles: A Review.Frontiers in veterinary science · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rafal TokarzCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, NY 10032, USA.
Stephen SameroffCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, NY 10032, USA.
Richard A HesseKansas State Veterinary Diagnostic Laboratory and Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS, 66508, USA.
Ben M HauseKansas State Veterinary Diagnostic Laboratory and Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS, 66508, USA.
Aaloki DesaiCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, NY 10032, USA.
Komal JainCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, NY 10032, USA.
W Ian LipkinCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, NY 10032, USA.
Columbia University · USKansas State University · US

Funding

Translational CoreU19AI109761 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARIC, RALPH S · 2014 to 2018
$32.6M
NIAID NIH HHS 1U19AI109761NIAID NIH HHS U19 AI109761
6 · The paper itself

Abstract

The family Coronaviridae represents a diverse group of vertebrate RNA viruses, all with genomes greater than 26,000 nt. Here, we report the discovery and genetic characterization of a novel virus present in cattle with respiratory disease. Phylogenetic characterization of this virus revealed that it clusters within the subfamily Torovirinae, in the family Coronaviridae. The complete genome consists of only 20,261 nt and represents the smallest reported coronavirus genome. We identified seven ORFs, including the canonical nidovirus ORF1a and ORF1b. Analysis of polyprotein 1ab revealed that this virus, tentatively named bovine nidovirus (BoNV), shares the highest homology with the recently described python-borne nidoviruses and contains several conserved nidovirus motifs, but does not encode the NendoU or O-MT domains that are present in other viruses within the family Coronaviridae. In concert with its reduced genome, the atypical domain architecture indicates that this virus represents a unique lineage within the order Nidovirales.

Indexed as

AnimalsCattleCattle DiseasesGenome, ViralMolecular Sequence DataNidoviralesNidovirales InfectionsOpen Reading FramesPhylogenyRespiratory Tract Diseases

Identifiers

PMID25918239
PMCPMC4681066
OpenAlexW2074248599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.