ArticleDiabetes2015
A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes.
Article in Diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Effects of Uric Acid-Lowering Treatment on Glycemia: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2020Pooled it
- Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.PloS one · 2018Pooled it
- Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies.BMJ (Clinical research ed.) · 2017Pooled it
- Association between urate-lowering therapies and cognitive decline in community-dwelling older adults.Scientific reports · 2022Trial
- Opposing effects of sodium intake on uric acid and blood pressure and their causal implication.Journal of the American Society of Hypertension : JASH · 2016Trial
- A machine learning-based framework for predicting type 2 diabetes mellitus using hematological indices.American heart journal plus : cardiology research and practice · 2026Article
- Differential pathway profiles of uric acid and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) in predicting incident type 2 diabetes: a prospective cohort study.BMC endocrine disorders · 2026Article
- Neuregulin 4-dependent MAPK amplification mediates urate-induced β-cell dysfunction.Journal of diabetes investigation · 2026Article
- Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways.Endocrinology, diabetes & metabolism · 2026Review
- Development of Hyperuricemia and Hyperglycemia After Prolonged Consumption of Clams (Food science & nutrition · 2026Article
- Genetically predicted serum urate and cancer risk: a Mendelian randomization study.Scandinavian journal of rheumatology · 2025Article
- Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner.BMC medicine · 2025Article
- The relationship between serum uric acid and accelerated aging in middle-aged and older adults: a prospective cohort study based on CHARLS.The journal of nutrition, health & aging · 2025Article
- The genetics of gout: translation into clinical practice.Therapeutic advances in musculoskeletal disease · 2025Review
- Gout and Hyperuricemia: A Narrative Review of Their Comorbidities and Clinical Implications.Journal of clinical medicine · 2024Review
- Hyperuricemia and its related diseases: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2024Review
- Uric acid and risk of gestational diabetes mellitus: an observational study and mendelian randomization analysis.Reproductive biology and endocrinology : RB&E · 2024Observational
- Uric acid is associated with type 2 diabetes: data mining approaches.Diabetology international · 2024Article
- SGLT2 Inhibitors and Uric Acid Homeostasis.Gout, urate, and crystal deposition disease · 2024Article
- Association of Serum Uric Acid with Indices of Insulin Resistance: Proposal of a New Model with Reference to Gender Differences.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
43 authors at 20 institutions in 9 countries.
Funding
Abstract
We aimed to investigate the causal effect of circulating uric acid concentrations on type 2 diabetes risk. A Mendelian randomization study was performed using a genetic score with 24 uric acid-associated loci. We used data of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, comprising 24,265 individuals of European ancestry from eight European countries. During a mean (SD) follow-up of 10 (4) years, 10,576 verified incident case subjects with type 2 diabetes were ascertained. Higher uric acid was associated with a higher diabetes risk after adjustment for confounders, with a hazard ratio (HR) of 1.20 (95% CI 1.11, 1.30) per 59.48 µmol/L (1 mg/dL) uric acid. The genetic score raised uric acid by 17 µmol/L (95% CI 15, 18) per SD increase and explained 4% of uric acid variation. By using the genetic score to estimate the unconfounded effect, we found that a 59.48 µmol/L higher uric acid concentration did not have a causal effect on diabetes (HR 1.01 [95% CI 0.87, 1.16]). Including data from the Diabetes Genetics Replication And Meta-analysis (DIAGRAM) consortium, increasing our dataset to 41,508 case subjects with diabetes, the summary odds ratio estimate was 0.99 (95% CI 0.92, 1.06). In conclusion, our study does not support a causal effect of circulating uric acid on diabetes risk. Uric acid-lowering therapies may therefore not be beneficial in reducing diabetes risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.