ArticleThe Journal of cell biology2015
The source of matrix-degrading enzymes in human cancer: Problems of research reproducibility and possible solutions.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- The extracellular matrix in inflammation and cancer.Molecular biomedicine · 2026Review
- Multi-omics reveals the immune and metabolic characteristics and associations in non-mucinous ovarian cancer.Journal of ovarian research · 2025Article
- Machine learning-based screening and validation of liver metastasis-specific genes in colorectal cancer.Scientific reports · 2024Article
- Extracellular matrix remodeling in the tumor immunity.Frontiers in immunology · 2023Review
- Dissecting tumor microenvironment heterogeneity in syngeneic mouse models: insights on cancer-associated fibroblast phenotypes shaped by infiltrating T cells.Frontiers in immunology · 2023Article
- Drug repurposing-an emerging strategy in cancer therapeutics.Naunyn-Schmiedeberg's archives of pharmacology · 2022Review
- Uncovering mediators of collagen degradation in the tumor microenvironment.Matrix biology plus · 2022Article
- Tertiary lymphoid structures accompanied by fibrillary matrix morphology impact anti-tumor immunity in basal cell carcinomas.Frontiers in medicine · 2022Article
- Liquid biopsy approaches and immunotherapy in colorectal cancer for precision medicine: Are we there yet?Frontiers in oncology · 2022Review
- Lost in transduction: Critical considerations when using viral vectors.Frontiers in cell and developmental biology · 2022Article
- Prognostic and immunotherapeutic significance of mannose receptor C type II in 33 cancers: An integrated analysis.Frontiers in molecular biosciences · 2022Article
- Curcumin May Prevent Basement Membrane Disassembly by Matrix Metalloproteinases and Progression of the Bladder Cancer.Nutrients · 2021Review
- Tumor-Associated Extracellular Matrix: How to Be a Potential Aide to Anti-tumor Immunotherapy?Frontiers in cell and developmental biology · 2021Review
- Immune Modulatory Properties of Collagen in Cancer.Frontiers in immunology · 2021Review
- Directionality of Macrophages Movement in Tumour Invasion: A Multiscale Moving-Boundary Approach.Bulletin of mathematical biology · 2020Article
- Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis.Scientific reports · 2020Article
- Collagen density regulates the activity of tumor-infiltrating T cells.Journal for immunotherapy of cancer · 2019Article
- Antimetastatic Potential of Garcinone E in Human Oral Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Expression of Proteolytic Enzymes by Small Cell Lung Cancer Circulating Tumor Cell Lines.Cancers · 2019Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Matrix degradation is central to tumor pathogenesis. Enzymes that degrade extracellular matrix are abundant in tumors. But which out of the complex mixture of cells that form a tumor produces them? Surprisingly, several hundred studies devoted to this question have provided confusion rather than clarity. Our analysis of these studies identifies likely reasons as to why this may be the case, which has implications for the broader issue of research reproducibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.