Evidence map›Paper›PMID 25918151›Full record

ArticleAntimicrobial agents and chemotherapy2015

Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators.

Zackery P Bulman, Mark D Sutton, Neang S Ly, Jurgen B Bulitta, Patricia N Holden, Roger L Nation, Jian Li, Brian T Tsuji

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Zackery P BulmanLaboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA.
Mark D SuttonDepartment of Biochemistry, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.
Neang S LyLaboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA The New York State Center of Excellence in Bioinformatics Life Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.ORCID http://orcid.org/0000-0002-5571-0347
Jurgen B BulittaLaboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Patricia N HoldenLaboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA The New York State Center of Excellence in Bioinformatics Life Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.
Roger L NationDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Jian LiDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Brian T TsujiLaboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA The New York State Center of Excellence in Bioinformatics Life Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA btsuji@buffalo.edu.
University at Buffalo, State University of New York · USMonash University · AU

Funding

Novel PK/PD Strategies for Polymyxin Combinations against Gram-negative SuperbugsR01AI111990 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LI, JIAN, TSUJI, BRIAN · 2014 to 2018
$4.4M
Regulation of DNA Replication and RepairR01GM066094 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SUTTON, MARK D. · 2003 to 2016
$4.0M
NIAID NIH HHS R01 AI111990NIGMS NIH HHS R01 GM066094
6 · The paper itself

Abstract

The interplay between polymyxin B pharmacodynamics and pathogenicity was examined in Pseudomonas aeruginosa PAO1 and isogenic DNA repair-deficient mutators (mutM and mutS strains). Against mutS mutators, polymyxin B initial killing was concentration dependent, with >99.9% bacterial reduction at 2 h followed by regrowth and resistance. The pre- versus postexposed strains were inoculated real time into Galleria mellonella waxworms, resulting in increased median survival times from 20 h to 23 h (P < 0.001). Emergence of resistance in mutS P. aeruginosa resulted in attenuation of virulence.

Indexed as

AnimalsAnti-Bacterial AgentsCystic FibrosisDNA RepairDrug Resistance, BacterialKaplan-Meier EstimateMicrobial Sensitivity TestsMothsMutationPolymyxin BPseudomonas aeruginosaPseudomonas InfectionsSurvivalSurvival AnalysisAnti-Bacterial AgentsPolymyxin B

Identifiers

PMID25918151
PMCPMC4468730
OpenAlexW1511787249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.