ArticleAntimicrobial agents and chemotherapy2015
First detection of AmpC β-lactamase bla(CMY-2) on a conjugative IncA/C plasmid in a Vibrio parahaemolyticus isolate of food origin.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Molecular insights into antimicrobial resistance in human bacterial pathogens: mechanisms, resistance genes, and translational diagnostic applications.Frontiers in microbiology · 2026Review
- Heavy Metal and Petroleum Hydrocarbon Contaminants Promote Resistance and Biofilm Formation inMicroorganisms · 2025Article
- Multidrug Resistance, Biofilm-Forming Ability, and Molecular Characterization ofAntibiotics (Basel, Switzerland) · 2025Article
- Antimicrobial susceptibility profile and molecular characterization ofMicrobiology spectrum · 2024Article
- Prevalence and molecular characterization of cefotaxime-resistantMicrobiology spectrum · 2023Article
- Identification and Genetic Characterization of Conjugative Plasmids Encoding Coresistance to Ciprofloxacin and Cephalosporin in FoodborneMicrobiology spectrum · 2023Article
- A Single Catalytic Endolysin Domain Plychap001: Characterization and Application to ControlFoods (Basel, Switzerland) · 2022Article
- Comparative Genomic Analysis of Third-Generation-Cephalosporin-Resistant Escherichia coli Harboring theAntimicrobial agents and chemotherapy · 2020Article
- Transmission of Chromosomal MDR DNA Fragment Encoding Ciprofloxacin Resistance by a Conjugative Helper Plasmid inFrontiers in microbiology · 2020Article
- Evolution of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae by Acquisition ofAntimicrobial agents and chemotherapy · 2019Article
- An IncR Plasmid Harbored by a Hypervirulent Carbapenem-ResistantAntimicrobial agents and chemotherapy · 2019Article
- Transmission of ciprofloxacin resistance inEmerging microbes & infections · 2019Article
- Genetic Characterization ofFrontiers in microbiology · 2019Article
- Evolution and transmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance in Salmonella.Emerging microbes & infections · 2019Article
- blaEnvironmental science and pollution research international · 2018Article
- LptD is a promising vaccine antigen and potential immunotherapeutic target for protection against Vibrio species infection.Scientific reports · 2016Article
- Polar flagella rotation in Vibrio parahaemolyticus confers resistance to bacteriophage infection.Scientific reports · 2016Article
- Characterization of an IncA/C Multidrug Resistance Plasmid in Vibrio alginolyticus.Antimicrobial agents and chemotherapy · 2016Article
- Reduced Susceptibility to Extended-Spectrum β-Lactams inFrontiers in public health · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio parahaemolyticus is an important causative agent of gastroenteritis, with the consumption of contaminated seafood being the major transmission route. Resistance to penicillin is common among V. parahaemolyticus strains, whereas cephalosporin resistance remains rare. In an attempt to assess the current prevalence and characteristics of antibiotic resistance of this pathogen in common food samples, a total of 54 (17% of the total samples) V. parahaemolyticus strains were isolated from 318 meat and seafood samples purchased from supermarkets and wet markets in Shenzhen, China, in 2013. These isolates exhibited high-level resistance to ampicillin, yet they were mostly susceptible to other antimicrobials, except for two that were resistant to extended-spectrum cephalosporins. The β-lactamase gene blaPER-1 was detectable in one strain, V. parahaemolyticus V43, which was resistant to both third- and fourth-generation cephalosporins. Compared to other blaPER-1-positive V. parahaemolyticus strains reported in our previous studies, strain V43 was found to harbor an ∼200-kb conjugative plasmid carrying genes that were different from the antimicrobial resistance genes reported from the previous studies. The β-lactamase gene blaCMY-2 was detectable for the first time in another V. parahaemolyticus isolate, V4, which was resistant to third-generation cephalosporins. This blaCMY-2 gene was shown to be located in an ∼150-kb IncA/C-type conjugative plasmid with a genetic structure consisting of traB-traV-traA-ISEcp1-blaCMY-2-blc-sugE-encR-orf1-orf2-orf3-orf4-dsbC-traC, which is identical to that of other IncA/C conjugative plasmids in Enterobacteriaceae, albeit with a different size. These findings indicate that the transmission of extended-spectrum-β-lactamase (ESBL) and AmpC β-lactamase genes via conjugative plasmids can mediate the development of extended-spectrum cephalosporin resistance in V. parahaemolyticus, thereby posing a potential threat to public health.
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