ArticleAntimicrobial agents and chemotherapy2015
Silver oxynitrate, an unexplored silver compound with antimicrobial and antibiofilm activity.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- In Vitro and In Vivo Antibacterial and Antibiofilm Activity of Zinc Sulfate (ZnSOAntibiotics (Basel, Switzerland) · 2025Article
- Anti-Biofilm Strategies: A Focused Review on Innovative Approaches.Microorganisms · 2024Review
- Synergistic Effect of Silver Nanoparticles with Antibiotics for Eradication of Pathogenic Biofilms.Current pharmaceutical biotechnology · 2024Article
- Anti-biofilm effects and healing promotion by silver oxynitrate-based dressings.Scientific reports · 2023Article
- Metallic Nanosystems in the Development of Antimicrobial Strategies with High Antimicrobial Activity and High Biocompatibility.International journal of molecular sciences · 2023Review
- Antibacterial, Antibiofilm, and Antioxidant Activity of 15 Different Plant-Based Natural Compounds in Comparison with Ciprofloxacin and Gentamicin.Antibiotics (Basel, Switzerland) · 2022Article
- Synthesis and Structural and Spectroscopic Studies of a pH-Neutral Argentic Chelate Complex: Tribasic Silver (III) Bisperiodate.ACS omega · 2021Article
- Evolution of biofilm-forming pathogenic bacteria in the presence of nanoparticles and antibiotic: adaptation phenomena and cross-resistance.Journal of nanobiotechnology · 2021Article
- Bacterial Biofilm Inhibition: A Focused Review on Recent Therapeutic Strategies for Combating the Biofilm Mediated Infections.Frontiers in microbiology · 2021Review
- Silver Antibacterial Synergism Activities with Eight Other Metal(loid)-Based Antimicrobials againstAntibiotics (Basel, Switzerland) · 2020Article
- The Effects of Silver Sulfadiazine on Methicillin-ResistantMicroorganisms · 2020Article
- Multiple Compounds Secreted bymSystems · 2020Article
- Specificity in the Susceptibilities ofAntibiotics (Basel, Switzerland) · 2019Article
- Using a Chemical Genetic Screen to Enhance Our Understanding of the Antibacterial Properties of Silver.Genes · 2018Article
- Influence of growth media components on the antibacterial effect of silver ions on Bacillus subtilis in a liquid growth medium.Scientific reports · 2018Article
- The efficacy of different anti-microbial metals at preventing the formation of, and eradicating bacterial biofilms of pathogenic indicator strains.The Journal of antibiotics · 2017Article
- Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing - A feasibility study.PloS one · 2017Article
- Orthopaedic device-related infection: current and future interventions for improved prevention and treatment.EFORT open reviews · 2016Article
- Preventing Implant-Associated Infections by Silver Coating.Antimicrobial agents and chemotherapy · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Historically it has been accepted, and recent research has established, that silver (Ag) is an efficacious antimicrobial agent. A dwindling pipeline of new antibiotics, combined with an increase in the number of antibiotic-resistant infections, is bringing Ag to the fore as a therapeutic compound to treat infectious diseases. Currently, many formulations of Ag are being deployed for commercial and medical purposes, with various degrees of effectiveness at killing microbial cells. Here, we evaluated the antimicrobial and antibiofilm capacity of our lead compound, silver oxynitrate [Ag(Ag3O4)2NO3 or Ag7NO11], against other metal compounds with documented antimicrobial activity, including Ag2SO4, AgNO3, silver sulfadiazine (AgSD), AgO, Ag2O, and CuSO4. Our findings reveal that Ag7NO11 eradicates biofilm and planktonic populations of Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, uropathogenic Escherichia coli (UPEC), fluoroquinolone-resistant Pseudomonas aeruginosa (FQRP), and methicillin-resistant Staphylococcus aureus (MRSA) at lower concentrations than those of the other tested metal salts. Altogether, our results demonstrate that Ag7NO11 has an enhanced efficacy for the treatment of biofilm-forming pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.