Evidence map›Paper›PMID 25917998›Full record

ArticleThe Journal of surgical research2015

Does levothyroxine administration impact parathyroid localization?

Rachell R Ayers, Kirby Tobin, Rebecca S Sippel, Courtney Balentine, Dawn Elfenbein, Herbert Chen, David F Schneider

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rachell R AyersSection of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin.
Kirby TobinUniversity of Oregon, Eugene, Oregon.
Rebecca S SippelSection of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin.
Courtney BalentineSection of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin.
Dawn ElfenbeinSection of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin.
Herbert ChenSection of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin.
David F SchneiderSection of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin. Electronic address: schneiderd@surgery.wisc.edu.
University of Wisconsin–Madison · USUniversity of Oregon · USUniversity of Wisconsin System · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
Surgery Summer Research Experience for Medical StudentsT35DK062709 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MEZRICH, JOSHUA D · 2006 to 2023
$870k
NCATS NIH HHS KL2 TR000428NCATS NIH HHS KL2TR000428NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1TR000427NIDDK NIH HHS T35 DK062709
6 · The paper itself

Abstract

backgroundProper localization is crucial in performing minimally invasive parathyroidectomy for primary hyperparathyroidism. Ultrasonography (US) and Tc-99m sestamibi (MIBI) scintigraphy are common methods used for localization. As the appearance and activity of the thyroid gland may impact parathyroid localization, the purpose of this study was to determine how exogenous use of the thyroid hormone, levothyroxine (LT), affects parathyroid localization.

methodsAdult patients with non-familial primary hyperparathyroidism who underwent initial parathyroidectomy from 2000-2014 were retrospectively identified. LT (+LT) and non-LT (-LT) patients were matched 1:3 based on age, gender, goiter status, and preoperative parathyroid hormone levels. Subgroup analysis was performed on patients previously treated with radioactive iodine and patients undergoing single adenoma resection.

resultsOf the 1737 patients that met inclusion criteria, 286 were on LT at the time of their parathyroid localization scan. Use of LT did not impact the percentage of correct MIBI localization scans when compared with -LT patients (P = 0.83). Interestingly, use of LT significantly hindered localization by US in comparison with the -LT group (48.4 versus 62.2%, P < 0.01). When examining only patients where a single upper gland was removed, the +LT group was less likely to have a correct US compared with the -LT group (50 versus 72.8%, P < 0.01). However, there was no difference in US accuracy for patients who only had a single lower gland removed (P = 0.51).

conclusionsExogenous LT is associated with impaired parathyroid localization with US but not MIBI. Surgeons should be aware of localization efficiency for this subset of patients in the era of personalized medicine and cost effectiveness.

Indexed as

Technetium Tc 99m SestamibiAdenomaAgedFemaleHumansMaleMiddle AgedParathyroidectomyParathyroid GlandsParathyroid NeoplasmsRadionuclide ImagingRetrospective StudiesThyroxineTechnetium Tc 99m SestamibiThyroxineLevothyroxinePreoperative localizationPrimary hyperparathyroidismSestamibi scintigraphyUltrasound

Identifiers

PMID25917998
PMCPMC4793941
OpenAlexW2010263571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.