ArticleMagnetic resonance in medicine2016
(13)C MRS of human brain at 7 Tesla using [2-(13)C]glucose infusion and low power broadband stochastic proton decoupling.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Implementation of Two-pulse Phase-modulated (TPPM)Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Multinuclear Magnetic Resonance Spectroscopy at Ultra-High-Field: Assessing Human Cerebral Metabolism in Healthy and Diseased States.Metabolites · 2023Review
- Monte Carlo study of metabolite correlations originating from spectral overlap.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- In VivoNeurochemical research · 2022Review
- Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference.Cell metabolism · 2020Article
- Selective proton-observed, carbon-edited (selPOCE) MRS method for measurement of glutamate and glutamineMagnetic resonance in medicine · 2018Article
- Proton-decoupled carbon magnetic resonance spectroscopy in human calf muscles at 7 T using a multi-channel radiofrequency coil.Scientific reports · 2018Article
- Determining the Rate of Carbonic Anhydrase Reaction in the Human Brain.Scientific reports · 2018Article
- Oxidation of [U-Magnetic resonance in medicine · 2017Article
- Reconstruction of randomly under-sampled spectra for in vivoMagnetic resonance imaging · 2017Article
- High FieldFrontiers in physics · 2017Article
- How Energy Metabolism Supports Cerebral Function: Insights fromFrontiers in neuroscience · 2017Review
- Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Review
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7 authors.
Funding
Abstract
purposeCarbon-13 ((13)C) MR spectroscopy (MRS) of the human brain at 7 Tesla (T) may pose patient safety issues due to high radiofrequency (RF) power deposition for proton decoupling. The purpose of present work is to study the feasibility of in vivo (13)C MRS of human brain at 7 T using broadband low RF power proton decoupling.
methodsCarboxylic/amide (13)C MRS of human brain by broadband stochastic proton decoupling was demonstrated on a 7 T scanner. RF safety was evaluated using the finite-difference time-domain method. (13)C signal enhancement by nuclear Overhauser effect (NOE) and proton decoupling was evaluated in both phantoms and in vivo.
resultsAt 7 T, the peak amplitude of carboxylic/amide (13)C signals was increased by a factor of greater than 4 due to the combined effects of NOE and proton decoupling. The 7 T (13)C MRS technique used decoupling power and average transmit power of less than 35 watts (W) and 3.6 W, respectively.
conclusionIn vivo (13)C MRS studies of human brain can be performed at 7 T, well below the RF safety threshold, by detecting carboxylic/amide carbons with broadband stochastic proton decoupling.
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