ArticleJournal of bacteriology2015
The interaction between Streptococcus spp. and Veillonella tobetsuensis in the early stages of oral biofilm formation.
Article in Journal of bacteriology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- From culture-based to 16S sequencing approaches: oral microbiota changes in aging, frailty, and oral hypofunction - a systematic review.BMC oral health · 2026Pooled it
- Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal.Genome biology · 2022Pooled it
- Intestinal microbiome analysis demonstrates azithromycin post-treatment effects improve when combined with lactulose.World journal of pediatrics : WJP · 2020Trial
- Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota.Genome medicine · 2016Trial
- Metagenomic analysis of oral microbiota in Chinese children with obesity.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Advances in Nanozyme Engineering for Precision Oral Health Management.International dental journal · 2026Review
- The Antimicrobial Efficacy of New Antibiotic Combinations against Bacteria Associated with Endo-perio Lesions in Deciduous Teeth: AnInternational journal of clinical pediatric dentistry · 2026Article
- Curcumin-Based Nanoformulations for Oral Health: Mechanistic Insights, Antimicrobial Efficacy, and Future Clinical Perspectives.Biomedicines · 2026Review
- Unique ecology of co-occurring functionally and phylogenetically undescribed species in the infant oral microbiome.PLoS computational biology · 2026Article
- Biological Validation of the PSC-MCAT: Analyzing Dental Plaque Microbiota Across Caries Risk Levels in Preschoolers.International dental journal · 2026Article
- Oral microbiota assessment at different time points during the first year of life: delivery mode and breastfeeding shape the bacterial community.International breastfeeding journal · 2026Article
- A Bayesian multivariate spatial point pattern model: application to oral microbiome FISH image data.Biostatistics (Oxford, England) · 2026Article
- The role ofFrontiers in oral health · 2026Review
- Cross-organ microbes modulate host upper gastrointestinal health and disease via the oral-gastric microbiome axis.Frontiers in cellular and infection microbiology · 2026Review
- MNetClass: a control-free microbial network clustering framework for identifying central subcommunities across ecological niches.mSystems · 2025Article
- Article
- First-year dynamics of the anaerobic microbiome and archaeome in infants' oral and gastrointestinal systems.mSystems · 2025Article
- Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis.World journal of gastroenterology · 2025Review
- Alterations of oral microbiota and cytokines profile in children and young adults with type 1 diabetes.Frontiers in endocrinology · 2025Article
- Distribution status and influencing factors of antibiotic resistance genes in the Chaohu Lake, China.PeerJ · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental plaque is a multispecies oral biofilm, the development of which is initiated by adherence of the pioneer Streptococcus spp. Oral Veillonella spp., including V. atypica, V. denticariosi, V. dispar, V. parvula, V. rogosae, and V. tobetsuensis, are known as early colonizers in oral biofilm formation. These species have been reported to co-aggregate with Streptococcus spp. in a metabolic cooperation-dependent manner to form biofilms in human oral cavities, especially in the early stages of biofilm formation. However, in our previous study, Streptococcus gordonii showed biofilm formation to the greatest extent in the presence of V. tobetsuensis, without co-aggregation between species. These results suggest that V. tobetsuensis produces signaling molecules that promote the proliferation of S. gordonii in biofilm formation. It is well known in many bacterial species that the quorum-sensing (QS) system regulates diverse functions such as biofilm formation. However, little is known about the QS system with autoinducers (AIs), between Veillonella and Streptococcus. Recently, AI-1 and AI-2 were detected and identified in the culture supernatants of V. tobetsuensis as strong signaling molecules in biofilm formation with S. gordonii. In particular, the supernatant from V. tobetsuensis showed the highest AI-2 activity among 6 oral Veillonella species, indicating that AIs, mainly AI-2, produced by V. tobetsuensis may be important factors and may facilitate biofilm formation of S. gordonii. Clarifying the mechanism that underlies the QS system between S. gordonii and V. tobetsuensis may lead to the development of novel methods for the prevention of oral infectious diseases caused by oral biofilms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.