Trial reportInternational archives of occupational and environmental health2016
Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity.
Trial report in International archives of occupational and environmental health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Multiple Chemical Sensitivity: Review of the State of the Art in Epidemiology, Diagnosis, and Future Perspectives.Journal of occupational and environmental medicine · 2018Pooled it
- Comparable responses to a wide range of olfactory stimulation in women and men.Scientific reports · 2023Article
- Laboratory Test Results in Patients with Workplace Moisture Damage Associated Symptoms-The SAMDAW Study.Healthcare (Basel, Switzerland) · 2023Article
- Central Sensitization in Migraine: A Narrative Review.Journal of pain research · 2022Review
- Multiple Chemical Sensitivity in Patients Exposed to Moisture Damage at Work and in General Working-Age Population-The SAMDAW Study.International journal of environmental research and public health · 2021Article
- Olfaction in patients with Parkinson's disease: a new threshold test analysis through turning points trajectories.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Wearable Sensors for Assessing the Role of Olfactory Training on the Autonomic Response to Olfactory Stimulation.Sensors (Basel, Switzerland) · 2021Article
- Multiple Chemical Sensitivity Syndrome: A Principal Component Analysis of Symptoms.International journal of environmental research and public health · 2020Article
- Olfactory-Related Quality of Life in Multiple Chemical Sensitivity: A Genetic-Acquired Factors Model.International journal of molecular sciences · 2019Article
- Chemical intolerance: involvement of brain function and networks after exposure to extrinsic stimuli perceived as hazardous.Environmental health and preventive medicine · 2019Review
- Observational cross-sectional study on Symptoms Associated to Moisture DAmage at Workplace: the SAMDAW study protocol.BMJ open · 2019Observational
- Recent insights into 3 underrecognized conditions: Myalgic encephalomyelitis-chronic fatigue syndrome, fibromyalgia, and environmental sensitivities-multiple chemical sensitivity.Canadian family physician Medecin de famille canadien · 2018Article
- Article
- Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session.BMJ open · 2017Article
- Multidimensional assessment of self-reported chemical intolerance and its impact on chemosensory effects during ammonia exposure.International archives of occupational and environmental health · 2016Article
- Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity.PloS one · 2015Article
- Insights from the third international conference on hyperacusis: causes, evaluation, diagnosis, and treatment.Noise & healthArticle
- Repeated pulmonary exposures to zinc ions enhance inflammatory responses to subsequent metal exposures.Experimental lung researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMultiple chemical sensitivity (MCS) is a prevalent medically unexplained symptom characterized by symptom reactions to everyday chemical exposure below hygienic thresholds. The aim of this study was to investigate the expressions of hyper-reactivity in MCS during whole-body exposure to low concentrations of the odorant n-butanol.
methodsWe exposed 18 participants with MCS and 18 non-ill controls to a low concentration of the odorant n-butanol using an exposure chamber. The first 10 min constituted blank exposure, after which the n-butanol concentration increased and reached a plateau at 11.5 mg/m(3).
resultsMCS participants, compared with controls, reported greater perceived odor intensities, more unpleasantness to the exposure and increasing symptoms over time. MCS participants also expressed higher pulse rate and lower pulse rate variability than controls did. No group differences were found for breathing rate or tonic electrodermal activity responses.
conclusionsWe conclude that MCS sufferers differ from healthy controls in terms of autonomic responses, symptoms and chemosensory perception during chemical exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.