Epilepsy: Neonatal seizures still lack safe and effective treatment.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed.

1. A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.Annals of neurology · 2021
   Trial
2. WONOEP appraisal: Targeted therapy development for early onset epilepsies.Epilepsia · 2025
   Review
3. Don't Get BUM'd Out: Bumetanide May yet Prove Beneficial for Neonatal Seizures.Epilepsy currents · 2021
   Article
4. Novel Therapeutics for Neonatal Seizures.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
   Review
5. Neuroprotection ofMolecules (Basel, Switzerland) · 2021
   Article
6. Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels.Molecular brain · 2019
   Article
7. Mannitol decreases neocortical epileptiform activity during early brain development via cotransport of chloride and water.Neurobiology of disease · 2019
   Article
8. Time and sex dependent effects of magnesium sulphate on post-asphyxial seizures in preterm fetal sheep.The Journal of physiology · 2018
   Article
9. Transient ischemia facilitates neuronal chloride accumulation and severity of seizures.Annals of clinical and translational neurology · 2018
   Article
10. Acute symptomatic seizures in term neonates: Etiologies and treatments.Seminars in fetal & neonatal medicine · 2018
    Review
11. Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.Trends in neurosciences · 2017
    Review
12. Recent Advances in Neonatal Seizures.Current neurology and neuroscience reports · 2016
    Review
13. Bumetanide for neonatal seizures-back from the cotside.Nature reviews. Neurology · 2015
    Article
14. Diazepam effect during early neonatal development correlates with neuronal Cl(.).Annals of clinical and translational neurology · 2015
    Article
15. Mechanism-Based Treatment for Neonatal Seizures: Still on the Horizon.Epilepsy currents
    Article
16. Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.Epilepsy currents
    Article

Corrections and comments

• Commented on by
  Bumetanide for neonatal seizures-back from the cotside.2015
• Comment on
  Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial.2015

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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