ArticleJournal of the American Heart Association2015
Quantitative tissue-tracking cardiac magnetic resonance (CMR) of left atrial deformation and the risk of stroke in patients with atrial fibrillation.
Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04769310 (Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Atrial cardiomyopathy and incident ischemic stroke risk: a systematic review and meta-analysis.Journal of neurology · 2023Pooled it
- History of stroke as a predictor of high left atrial fibrosis in patients with persistent atrial fibrillation-insight from the DECAAF II randomized trial.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Trial
- Effects of dietary nitrate on cardiovascular reactivity in normotensive postmenopausal women.European journal of applied physiology · 2026Article
- Left atrial diastasis strain slope is a marker of hemodynamic recovery in post-ST elevation myocardial infarction: the Laser Atherectomy for STemi, Pci Analysis with Scintigraphy Study (LAST-PASS).Frontiers in radiology · 2024Article
- Three-Dimensional Automated, Machine-Learning-Based Left Heart Chamber Metrics: Associations with Prevalent Vascular Risk Factors and Cardiovascular Diseases.Journal of clinical medicine · 2022Article
- Validation of Biomarker-Based ABCD Score in Atrial Fibrillation Patients with a Non-Gender CHAYonsei medical journal · 2022Article
- Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study.European heart journal. Cardiovascular Imaging · 2022Article
- Atrial function and geometry differences in transthyretin versus immunoglobulin light chain amyloidosis: a cardiac magnetic resonance study.Scientific reports · 2022Article
- Left Atrial Dysfunction, Fibrosis and the Risk of Thromboembolism in Patients With Paroxysmal and Persistent Atrial Fibrillation.International journal of heart failure · 2022Article
- Left atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers.European heart journal. Cardiovascular Imaging · 2021Article
- Abnormal P-wave terminal force in lead VESC heart failure · 2021Article
- Comprehensive assessment of left atrial and ventricular remodeling in paroxysmal atrial fibrillation by the cardiovascular magnetic resonance myocardial extracellular volume fraction and feature tracking strain.Scientific reports · 2021Observational
- References Values for Left Atrial Volumes, Emptying Fractions, Strains, and Strain Rates and Their Determinants by Age, Gender, and Ethnicity: The Multiethnic Study of Atherosclerosis (MESA).Academic radiology · 2021Article
- Short- and long-term associations of atrial fibrillation catheter ablation with left atrial structure and function: A cardiac magnetic resonance study.Journal of cardiovascular electrophysiology · 2021Article
- Comparison of left atrial and left atrial appendage mechanics in the risk stratification of stroke in patients with atrial fibrillation.Cardiovascular ultrasound · 2021Article
- Cardiac MRI to Manage Atrial Fibrillation.Arrhythmia & electrophysiology review · 2020Review
- Rhythm Control in Heart Failure Patients with Atrial Fibrillation.Arrhythmia & electrophysiology review · 2020Review
- Atrial fibrillation: villain or bystander in vascular brain injury.European heart journal supplements : journal of the European Society of Cardiology · 2020Article
- An Image-based Approach for 3D Left Atrium Functional Measurements.Computing in cardiology · 2020Article
- Association between interatrial block, left atrial fibrosis, and mechanical dyssynchrony: Electrocardiography-magnetic resonance imaging correlation.Journal of cardiovascular electrophysiology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent evidence suggests that left atrial (LA) dysfunction may be mechanistically contributing to cerebrovascular events in patients with atrial fibrillation (AF). We investigated the association between regional LA function and a prior history of stroke during sinus rhythm in patients referred for catheter ablation of AF. METHODS AND
resultsA total of 169 patients (59 ± 10 years, 74% male, 29% persistent AF) with a history of AF in sinus rhythm at the time of pre-ablation cardiac magnetic resonance (CMR) were analyzed. The LA volume, emptying fraction, strain (S), and strain rate (SR) were assessed by tissue-tracking cardiac magnetic resonance. The patients with a history of stroke or transient ischemic attack (n=18) had greater LA volumes (Vmax and Vmin; P=0.02 and P<0.001, respectively), lower LA total emptying fraction (P<0.001), lower LA maximum and pre-atrial contraction strains (Smax and SpreA; P<0.001 and P=0.01, respectively), and lower absolute values of LA SR during left ventricular (LV) systole and early diastole (SRs and SRe; P=0.005 and 0.03, respectively) than those without stroke/transient ischemic attack (n=151). Multivariable analysis demonstrated that the LA reservoir function, including total emptying fraction, Smax, and SRs, was associated with stroke/transient ischemic attack (odds ratio 0.94, 0.91, and 0.17; P=0.03, 0.02, and 0.04, respectively) after adjusting for the CHA2DS2-VASc score and LA Vmin.
conclusionsDepressed LA reservoir function assessed by tissue-tracking cardiac magnetic resonance is significantly associated with a prior history of stroke/transient ischemic attack in patients with AF. Our findings suggest that assessment of LA reservoir function can improve the risk stratification of cerebrovascular events in AF patients.
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Registered trials
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