Evidence map›Paper›PMID 25917284›Full record

ArticleHead & neck2016

Translational treatment paradigm for managing non-unions secondary to radiation injury utilizing adipose derived stem cells and angiogenic therapy.

Alexis Donneys, Jordan T Blough, Noah S Nelson, Joseph E Perosky, Sagar S Deshpande, Stephen Y Kang, Peter A Felice, Christian Figueredo, Jonathan R Peterson, Kenneth M Kozloff and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The sole use of stem cells in treating fracture nonunion: a scoping review.Archives of orthopaedic and trauma surgery · 2025
    Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Alexis DonneysCraniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, Michigan.
Jordan T BloughCraniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, Michigan.
Noah S NelsonCraniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, Michigan.
Joseph E PeroskyOrthopedic Research Laboratories, Department of Orthopedic Surgery, University of Michigan, Ann Arbor, Michigan.
Sagar S DeshpandeCraniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, Michigan.
Stephen Y KangDepartment of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Peter A FeliceCraniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, Michigan.
Christian FigueredoCraniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, Michigan.
Jonathan R PetersonCraniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, Michigan.
Kenneth M KozloffOrthopedic Research Laboratories, Department of Orthopedic Surgery, University of Michigan, Ann Arbor, Michigan.
Benjamin LeviCraniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, Michigan.
Douglas B ChepehaDepartment of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Steven R BuchmanCraniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, Michigan.
University of Michigan–Ann Arbor · USUniversity of South Carolina · US

Funding

TRAINING GRANT IN TRAUMA, BURN AND WOUND HEALING RESEARCT32GM008616 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUCHMAN, STEVEN R, CHUNG, KEVIN C · 1997 to 2025
$3.1M
Translational Optimization of Bone Regeneration in the Irradiated MandibleR01CA125187 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUCHMAN, STEVEN R · 2007 to 2017
$2.8M
NCI NIH HHS R01 CA125187NIGMS NIH HHS T32 GM008616
6 · The paper itself

Abstract

backgroundBony non-unions arising in the aftermath of collateral radiation injury are commonly managed with vascularized free tissue transfers. Unfortunately, these procedures are invasive and fraught with attendant morbidities. This study investigated a novel, alternative treatment paradigm utilizing adipose-derived stem cells (ASCs) combined with angiogenic deferoxamine (DFO) in the rat mandible.

methodsRats were exposed to a bioequivalent dose of radiation and mandibular osteotomy. Those exhibiting non-unions were subsequently treated with surgical debridement alone or debridement plus combination therapy. Radiographic and biomechanical outcomes were assessed after healing.

resultsSignificant increases in biomechanical strength and radiographic metrics were observed in response to combination therapy (p < .05). Importantly, combined therapy enabled a 65% reduction in persisting non-unions when compared to debridement alone.

conclusionWe support the continued investigation of this promising combination therapy in its potential translation for the management of radiation-induced bony pathology. © 2015 Wiley Periodicals, Inc. Head Neck 38: E837-E843, 2016.

Indexed as

Stem Cell TransplantationAdipose TissueAnimalsDebridementDeferoxamineFractures, UnunitedMandibleRadiation InjuriesRatsRats, Sprague-DawleyStem CellsDeferoxamineadipose-derived stromal celldeferoxamineosteoradionecrosispathologic fractureradiotherapy

Identifiers

PMID25917284
PMCPMC4624054
OpenAlexW1901822182

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.