ArticleAnnals of biomedical engineering2015
Prediction and Validation of Load-Dependent Behavior of the Tibiofemoral and Patellofemoral Joints During Movement.
Article in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- The non-invasive evaluation technique of patellofemoral joint stress: a systematic literature review.Frontiers in bioengineering and biotechnology · 2023Pooled it
- Valgus bracing can relocate cartilage contact pressure away from bone marrow lesions and full-thickness cartilage defects in varus-malaligned medial knee osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- A Musculoskeletal-Finite Element Study of Knee Joint Loading and Cartilage Mechanics in Children with Cerebral Palsy.Annals of biomedical engineering · 2026Article
- Neural Network-Driven Finite Element Modeling for Estimating Knee Joint Cartilage Mechanical Responses.Annals of biomedical engineering · 2026Article
- Personalized musculoskeletal models show that gait biofeedback alters knee cartilage contact mechanics in ACL-reconstructed subjects.Journal of biomechanics · 2026Article
- Altered gait strategies show inconsistent medial compartment unloading in varus medial knee osteoarthritis awaiting high tibial osteotomy.Clinical biomechanics (Bristol, Avon) · 2026Article
- Digital Twins in Orthopedics and Trauma: Concepts, Emerging Evidence, and Barriers to Clinical Translation.Journal of clinical medicine · 2026Review
- Reducing Complexity in Muscle-Tendon Kinematics Parameterization Improves Convergence Speed in Musculoskeletal Simulations.International journal for numerical methods in biomedical engineering · 2026Article
- Assessing sensitivity of predictive shoulder simulations to uncertain soft tissue properties.Journal of biomechanics · 2026Article
- Tibiofemoral Joint Contact Force Profiles of Pediatric Patients After Anterior Cruciate Ligament Reconstruction.The American journal of sports medicine · 2025Article
- Cartilage mechanical responses during gait as in silico biomarkers for medial knee OA progression.Scientific reports · 2025Article
- Does Valgus Bracing Reduce Estimates of Medial Tibial, Medial Femoral, and Patella Cartilage Contact Pressure in Varus Malaligned Medial Knee Osteoarthritis?Clinical orthopaedics and related research · 2025Article
- Reduced Muscle Strength Can Alter the Impact of Gait Modifications on Knee Cartilage Mechanics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- A PRISMA systematic review through time on predictive musculoskeletal simulations.Journal of neuroengineering and rehabilitation · 2025Article
- The impact of PCA derived gait kinematic variations on estimated medial knee contact forces in a knee osteoarthritis population.Scientific reports · 2025Article
- Modeling the future of shoulder arthroplasty.JSES international · 2025Article
- On the consequences of intra-operative release versus over-tensioning of the posterior cruciate ligament in total knee arthroplasty.Journal of the Royal Society, Interface · 2024Article
- Patient-specific gait pattern in individuals with patellofemoral instability reduces knee joint loads.Scientific reports · 2024Article
- Recent developments in computational modelling of the knee.Osteoarthritis imaging · 2024Article
- Validation and evaluation of subject-specific finite element models of the pediatric knee.Scientific reports · 2023Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The study objective was to construct and validate a subject-specific knee model that can simulate full six degree of freedom tibiofemoral and patellofemoral joint behavior in the context of full body movement. Segmented MR images were used to reconstruct the geometry of 14 ligament bundles and articular cartilage surfaces. The knee was incorporated into a lower extremity musculoskeletal model, which was then used to simulate laxity tests, passive knee flexion, active knee flexion, and human walking. Simulated passive and active knee kinematics were shown to be consistent with subject-specific measures obtained via dynamic MRI. Anterior tibial translation and internal tibial rotation exhibited the greatest variability when uncertainties in ligament properties were considered. When used to simulate walking, the model predicted knee kinematic patterns that differed substantially from passive joint behavior. Predictions of ean knee cartilage contact pressures during normal gait reached 6.2 and 2.8 Pa on the medial tibial plateau and patellar facets, respectively. Thus, the dynamic modeling framework can be used to simulate the interaction of soft tissue loads and cartilage contact during locomotion activities, and therefore provides a basis to simulate the effects of soft tissue injury and surgical treatment on functional knee mechanics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.