ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Tumor-associated and disease-associated autoantibody repertoires in healthy colostrum and maternal and newborn cord sera.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Do human B-1 lymphocytes truly exist?Frontiers in immunology · 2026Review
- Transient Neonatal Myasthenia Gravis as a Common Complication of a Rare Disease: A Systematic Review.Journal of clinical medicine · 2024Review
- Glycan Reactive Natural Antibodies and Viral Immunity.Viral immunology · 2020Review
- Antibodies specific for disease-associated antigens (DAA) expressed in non-malignant diseases reveal potential new tumor-associated antigens (TAA) for immunotherapy or immunoprevention.Seminars in immunology · 2020Review
- Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures.BMC bioinformatics · 2019Article
- The Immune System Computes the State of the Body: Crowd Wisdom, Machine Learning, and Immune Cell Reference Repertoires Help Manage Inflammation.Frontiers in immunology · 2019Review
- Anti-glycan IgM repertoires in newborn human cord blood.PloS one · 2019Article
- Evolution, immunity and the emergence of brain superautoantigens.F1000Research · 2017Article
- Editorial: Natural Antibodies in Health and Disease.Frontiers in immunology · 2017Article
- BP180 Is Critical in the Autoimmunity of Bullous Pemphigoid.Frontiers in immunology · 2017Review
- Autoimmunity as a Driving Force of Cognitive Evolution.Frontiers in neuroscience · 2017Article
- Defining Natural Antibodies.Frontiers in immunology · 2017Article
- Clonal selection versus clonal cooperation: the integrated perception of immune objects.F1000Research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we studied autoantibody repertoires and Ig isotypes in 71 mothers and their 104 healthy newborns (including twins and triplets delivered term or premature). Newborns receive maternal IgG Abs via the placenta before birth, but developing infants must produce their own IgM and IgA Abs. We used an Ag microarray analysis to detect binding to a selection of 295 self-Ags, compared with 27 standard foreign Ags. The magnitude of binding to specific self-Ags was found to be not less than that to the foreign Ags. As expected, each newborn shared with its mother a similar IgG repertoire-manifest as early as the 24th week of gestation. IgM and IgA autoantibody repertoires in cord sera were highly correlated among the newborns and differed from their mothers' repertoires; the latter differed in sera and milk. The autoantibodies bound to self-Ags known to be associated with tumors and to autoimmune diseases. Thus, autoantibody repertoires in healthy humans--the immunological homunculus--arise congenitally, differ in maternal milk and sera, and mark the potential of the immune system to attack tumors, beneficially, or healthy tissues, harmfully; regulation of the tissue site, the dynamics, and the response phenotype of homuncular autoimmunity very likely affects health.
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Registered trials
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