Evidence map›Paper›PMID 25917068›Full record

ArticleBMJ case reports2015

Periventricular white matter lesion and incomplete MRZ reaction in a male patient with anti-N-methyl-D-aspartate receptor encephalitis presenting with dysphoric mania.

Maximilian Gahr, Florian Lauda, Moritz E Wigand, Bernhard J Connemann, Angela Rosenbohm, Hayrettin Tumani, Markus Reindl, Zeljko Uzelac, Jan Lewerenz

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Maximilian GahrDepartment of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany.
Florian LaudaDepartment of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany.
Moritz E WigandDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.
Bernhard J ConnemannDepartment of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany.
Angela RosenbohmDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.
Hayrettin TumaniDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.
Markus ReindlClinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.
Zeljko UzelacDepartment of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany.
Jan LewerenzDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.
Universität Ulm · DEInnsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several findings suggest that there may be an overlap of anti-N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis with neuromyelitis optica spectrum disorders or acute demyelinating encephalomyelitis (ADEM)-like demyelination. We present a case of a patient with anti-NMDAR antibody encephalitis, who on MRI featured a single prominent T2-hyperintensive white matter lesion in the periventricular region, adjacent to the anterior horn of the left lateral ventricle. In view of the lesion location and the cerebrospinal fluid (CSF) findings (incomplete MRZ (measles, rubella and varicella zoster) reaction, lymphocytic pleocytosis, intrathecal IgG and IgM synthesis; absence of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibodies), the presence of a multiple sclerosis-like immune response was discussed. This case appears to add evidence to the hypothesis of an overlap between anti-NMDAR antibody encephalitis and other inflammatory central nervous system diseases.

Indexed as

AggressionNeuroimagingAdultAnti-N-Methyl-D-Aspartate Receptor EncephalitisAquaporin 4AutoantibodiesHumansImmunoglobulin GMagnetic Resonance ImagingMaleMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaViral VaccinesWhite MatterAQP4 protein, humanAquaporin 4AutoantibodiesImmunoglobulin GMOG protein, humanMyelin-Oligodendrocyte GlycoproteinViral Vaccines

Identifiers

PMID25917068
PMCPMC4422915
OpenAlexW2103907272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.