ArticleCytotechnology2016
The antioxidant and chemical properties of Berberis vulgaris and its cytotoxic effect on human breast carcinoma cells.
Article in Cytotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- Exploiting signal transduction pathways for cancer therapy: insights from natural products in preclinical models.Frontiers in pharmacology · 2026Review
- Biochemical, antioxidant activity, and phenological diversity among Berberis progenies in the FScientific reports · 2025Article
- Updated Review on Natural Polyphenols: Molecular Mechanisms, Biological Effects, and Clinical Applications for Cancer Management.Biomolecules · 2025Review
- Natural Food Colorant Obtained from WildFoods (Basel, Switzerland) · 2025Article
- Antioxidant and Cytotoxic Properties ofMolecules (Basel, Switzerland) · 2024Article
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- The Antioxidant, Antibacterial and Anti-Biofilm Properties of Rapeseed Creamed Honey Enriched with Selected Plant Superfoods.Antibiotics (Basel, Switzerland) · 2023Article
- Acetone extracts of BerberisTurkish journal of medical sciences · 2023Article
- Development of an Optimized Drying Process for the Recovery of Bioactive Compounds from the Autumn Fruits ofAntioxidants (Basel, Switzerland) · 2021Article
- Anticancer and apoptotic activities of parthenolide in combination with epirubicin in mda-mb-468 breast cancer cells.Molecular biology reports · 2020Article
- State of the Art of Anthocyanins: Antioxidant Activity, Sources, Bioavailability, and Therapeutic Effect in Human Health.Antioxidants (Basel, Switzerland) · 2020Review
- Isolation of Oxyberberine andEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Review
- Comparison of Anticancer Activity and HPLC-DAD Determination of Selected Isoquinoline Alkaloids fromMolecules (Basel, Switzerland) · 2019Article
- Involvement of 15-lipoxygenase-1 in the regulation of breast cancer cell death induced by sodium butyrate.Cytotechnology · 2016Article
- Protective effect ofAvicenna journal of phytomedicineArticle
- Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we evaluated the biological activity of alcoholic and aqueous extracts from the fruit of Berberis vulgaris. The total antioxidant capacity of Berberis was characterized by FRAP, DPPH, Folin-Ciocalteu while the anthocyanins content was measured by pH differential method. Cell viability and apoptotic property were determined by MTT and DNA fragmentation assays, respectively. Alcoholic extract of Berberis was richer in antioxidants and anthocyanins compared to aqueous extract. Although both extracts significantly inhibited proliferation of breast cancer cells (MCF-7); these changes were not observed in normal human breast epithelial cells (MCF10-A). The alcoholic extract was more effective in inducing apoptosis as detected by DNA fragmentation in treated cancer cells. Our results suggest that Berberis has potent antioxidant properties and cytotoxic effects that can induce apoptosis. Therefore, Berberis can potentially be exploited for the development of therapeutics to fight against human breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.