ArticleThe EMBO journal2015
Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly.
Article in The EMBO journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 173 citations in OpenAlex.
- Frequency-specific gyro-sulcal functional differentiation in preterm neonates: Sulcal dominance and gene expression correlates.Developmental cognitive neuroscience · 2026Article
- The cellular and molecular basis of gyrus-sulcus specialization in the primate brain.Nature communications · 2026Article
- A transcriptional atlas of gyrification reveals dynamic spatio-temporal gene expression in the developing ferret cortex.Brain structure & function · 2026Article
- Structuro-Functional Differentiation and Coupling of Gyri and Sulci in the Neonatal Cortex.Human brain mapping · 2026Article
- Progenitor diversity during formation of the mammalian neocortex.Frontiers in neuroscience · 2026Review
- Investigation of the mechanisms underlying the development and evolution of the mammalian cerebrum using gyrencephalic ferrets.Frontiers in cell and developmental biology · 2026Review
- A computational model of radial scaffolds in the human fetal brain based on MRI.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Astrocytes in white matter respond to tensile cues during cortical folding: a numerical study.bioRxiv : the preprint server for biology · 2025Article
- Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration.Nature communications · 2025Article
- The Principle of Cortical Development and Evolution.Neuroscience bulletin · 2025Review
- Microdissection and Single-Cell Suspension of Neocortical Layers From Ferret Brain for Single-Cell Assays.Bio-protocol · 2024Article
- Evolutionary changes leading to efficient glymphatic circulation in the mammalian brain.Nature communications · 2024Article
- The Control of Cortical Folding: Multiple Mechanisms, Multiple Models.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Article
- Gene regulatory landscape of cerebral cortex folding.Science advances · 2024Article
- The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex.The EMBO journal · 2024Article
- Multiple parallel cell lineages in the developing mammalian cerebral cortex.Science advances · 2024Article
- ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Association between placental oxygen transport and fetal brain cortical development: a study in monochorionic diamniotic twins.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients.bioRxiv : the preprint server for biology · 2023Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gyrencephalic species develop folds in the cerebral cortex in a stereotypic manner, but the genetic mechanisms underlying this patterning process are unknown. We present a large-scale transcriptomic analysis of individual germinal layers in the developing cortex of the gyrencephalic ferret, comparing between regions prospective of fold and fissure. We find unique transcriptional signatures in each germinal compartment, where thousands of genes are differentially expressed between regions, including ~80% of genes mutated in human cortical malformations. These regional differences emerge from the existence of discrete domains of gene expression, which occur at multiple locations across the developing cortex of ferret and human, but not the lissencephalic mouse. Complex expression patterns emerge late during development and map the eventual location of folds or fissures. Protomaps of gene expression within germinal layers may contribute to define cortical folds or functional areas, but our findings demonstrate that they distinguish the development of gyrencephalic cortices.
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