ArticlePlanta2015
Multiple evolution of flavonoid 3',5'-hydroxylase.
Article in Planta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Genome-Wide Datasets of Chicories (International journal of molecular sciences · 2023Pooled it
- The road less taken: Dihydroflavonol 4-reductase inactivation and delphinidin anthocyanin loss underpins a natural intraspecific flower colour variation.Molecular ecology · 2025Article
- Article
- The evolution of flavonoid biosynthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Genome-wide analysis of flavonoid biosynthetic genes in Musaceae (AoB PLANTS · 2024Article
- Heat Stress and Microbial Stress Induced Defensive Phenol Accumulation in Medicinal PlantInternational journal of molecular sciences · 2024Article
- Small RNA sequencing provides insights into molecular mechanism of flower development in Rhododendron pulchrum Sweet.Scientific reports · 2023Article
- Heterologous Expression ofGenes · 2023Article
- Vaccinium as a comparative system for understanding of complex flavonoid accumulation profiles and regulation in fruit.Plant physiology · 2023Article
- Comparative Transcriptome and Metabolome Analyses of Broccoli Germplasms with Purple and Green Curds Reveal the Structural Genes and Transitional Regulators Regulating Color Formation.International journal of molecular sciences · 2023Article
- First purified recombinant CYP75B including transmembrane helix with unexpected high substrate specificity to (2R)-naringenin.Scientific reports · 2022Article
- Identification, Analysis and Gene Cloning of the SWEET Gene Family Provide Insights into Sugar Transport in Pomegranate (International journal of molecular sciences · 2022Article
- The Common BeanFrontiers in plant science · 2022Article
- Article
- Metabolite Profiling and Transcriptome Analysis Provide Insight into Seed Coat Color inInternational journal of molecular sciences · 2021Article
- Tricin Biosynthesis and Bioengineering.Frontiers in plant science · 2021Review
- Assessment of violet-blue color formation in Phalaenopsis orchids.BMC plant biology · 2020Article
- Abnormal expression ofHorticulture research · 2020Article
- Proteomics Reveal the Profiles of Color Change inInternational journal of molecular sciences · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
MAIN
conclusionMultiple F3'5'H evolution from F3'H has occurred in dicotyledonous plants. Efficient pollinator attraction is probably the driving force behind, as this allowed for the synthesis of delphinidin-based blue anthocyanins. The cytochrome P450-dependent monooxygenases flavonoid 3'-hydroxylase (F3'H) and flavonoid 3',5'-hydroxylase (F3'5'H) hydroxylate the B-ring of flavonoids at the 3'- and 3'- and 5'-position, respectively. Their divergence took place early in plant evolution. While F3'H is ubiquitously present in higher plants, the distribution of F3'5'H is scattered. Here, we report that F3'5'H has repeatedly evolved from F3'H precursors at least four times in dicotyledonous plants: In the Asteraceae, we identified F3'5'Hs specific for the subfamilies Cichorioideae and Asteroideae, and additionally an F3'5'H that seems to be specific for the genus Echinops of the subfamily Carduoideae; moreover, characterisation of a sequence from Billardiera heterophylla (formerly Sollya heterophylla) (Pittosporaceae) showed that the independent evolution of an F3'5'H has occurred at least once also in another family. The evolution of F3'5'H from an F3'H precursor represents a gain of enzymatic function, probably triggered by an amino acid change at one position of substrate recognition site 6. The gain of F3'5'H activity allows for the synthesis of delphinidin-based anthocyanins which usually provide the basis for lilac to blue flower colours. Therefore, the need for an efficient pollinator attraction is probably the driving force behind the multiple F3'5'H evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.