ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
Dysregulation of zinc finger protein, X-linked (ZFX) impairs cell proliferation and induces apoptosis in human oral squamous cell carcinorma.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- De Novo Heterozygous ZFX Frameshift Variant in a Female With an X-Linked Neurodevelopmental Disorder.American journal of medical genetics. Part A · 2026Article
- The Role of Zinc Finger Proteins in Various Oral Conditions.TheScientificWorldJournal · 2022Review
- Sex-Associated Gene Expression Alterations Correlate With Esophageal Cancer Survival.Clinical and translational gastroenterology · 2020Article
- Article
- Zinc finger proteins in cancer progression.Journal of biomedical science · 2016Review
- Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811.American journal of translational research · 2016Article
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Authors and funding
8 authors.
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Abstract
Zinc finger protein, X-linked (ZFX) is a transcriptional factor involved in many physiological processes such as embryonic stem cell survival and self-renewal. Though ZFX dysfunctions have been identified in variant human diseases and especially in cancers, its pathological roles have not been fully addressed. Here, we explored the relationship between ZFX expression and squamous cell carcinoma (SCC) of the tongue. We found that ZFX expression was significantly higher in tongue SCC tumors as compared to tumor-adjacent normal tissues. Furthermore, ZFX knockdown impeded cell proliferation, impaired colony formation ability, and lead to cell cycle arrest while induced cell apoptosis in human tongue squamous cell carcinoma cell line Tca-8113. Our results provide evidence suggesting that ZFX overexpression is associated with the development of tongue SCC and ZFX knockdown is a potential treatment for tumor suppression.
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