← Statins × all-cause mortality

SynthesisPloS one2015

Clinical efficacy and safety of Ezetimibe on major cardiovascular endpoints: systematic review and meta-analysis of randomized controlled trials.

Alessandro Battaggia et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 2015

Randomised comparison

Probably increased deaths

1.3×1.1× to 2.2×

Bigger than 6 in 10 for all-cause mortality

As reported

HR 1.25, 95% CI 1.14–2.19 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on deaths

+4%−21% to +36%

Bigger than 1 in 10 for all-cause mortality

As reported

HR 1.04, 95% CI 0.79–1.36 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on deaths

2.5×0.7× to 9.7×

Bigger than almost all for all-cause mortality

As reported

RR 2.52, 95% CI 0.65–9.74 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on cardiovascular events

+2%−5% to +9%

Smaller than almost all for cardiovascular events

As reported

RR 1.02, 95% CI 0.95–1.09

+1 more in the walkthrough ↓

Five numbers in the abstract

the abstract, start to end

… group, and 100 in the placebo group (HR 1.04; 95% CI 0.79-1.36).

… vs. atorvastatin [30] (CV outcome HR 1.25; 95% CI 1.14-2.19; all-cause …

… for all outcomes (all-cause death RR 2.52, 95% CI 0.65-9.74; CV deaths …

… of E+simvastatin for allcause death (RR 1.02, 95% CI 0.95-1.09) and SAEs (RR …

… reduction of the risk of CV death (RR 0.93, 95% CI 0.80-1.07; and 0.83, …

← favours treatmentfavours comparator →
could be chance
All-cause mortality
HR 1.040.79–1.36
All-cause mortality
HR 1.251.14–2.19
All-cause mortality
RR 2.520.65–9.74
Cardiovascular events
RR 1.020.95–1.09
All-cause mortality
RR 0.930.80–1.07
StatinsOther lipid agentsCardiovascular eventsAll-cause mortality

Statins × all-cause mortalityhelps?mixed

unlikelylikely
0.50not counted

Other lipid agents × all-cause mortalityhelps?one trial

unlikelylikely
0.50not counted

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.86not counted
← favours treatmentfavours comparator →
more certainless certain
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19 papers cite it

2015
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 25915909