Evidence map›Paper›PMID 25915733›Full record

ArticleNature immunology2015

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.

Zihou Deng, Shixin Ma, Hao Zhou, Aiping Zang, Yiyuan Fang, Tiantian Li, Huanjing Shi, Mei Liu, Min Du, Patricia R Taylor and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 109 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 2 countries.

Zihou DengKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Shixin MaKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Hao ZhouDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Aiping ZangKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Yiyuan FangKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Tiantian LiKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Huanjing ShiKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Mei LiuKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Min DuKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Patricia R TaylorDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Ohio, USA.
Helen He ZhuState Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiangye ChenState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Guangxun MengKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Fubin LiShanghai Institute of Immunology and Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Changbin ChenKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Yan ZhangKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Xin-Ming JiaDepartment of Immunology, Tongji University School of Medicine, Shanghai, China.
Xin LinDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000000309563654
Xiaoming ZhangKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Eric PearlmanDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Ohio, USA.
Xiaoxia LiDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Gen-Sheng FengDepartment of Pathology and Division of Biological Sciences, University of California San Diego, La Jolla, California, USA.
Hui XiaoKey Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Institut Pasteur of Shanghai · CNCase Western Reserve University · USShanghai Jiao Tong University · CNChinese Academy of Sciences · CNCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USThe University of Texas MD Anderson Cancer Center · USTongji University · CNUniversity of California San Diego · US

Funding

Vascular Cell function and AtherosclerosisP01HL029582 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FOX, PAUL L · 1985 to 2019
$32.0M
Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI REIZES, OFER · 2011 to 2020
$26.8M
Pathogenesis of Fungal KeratitisR01EY018612 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PEARLMAN, ERIC · 2008 to 2022
$6.9M
Tyrosine Dephosphorylation and Blood Cell DevelopmentR01HL096125 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FENG, GEN-SHENG · 2009 to 2013
$1.9M
Shp2 and Pten in Leukemia and AnemiaR01HL129763 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FENG, GEN-SHENG · 2015 to 2018
$1.6M
NEI NIH HHS R01 EY018612NEI NIH HHS R01EY018612NHLBI NIH HHS P01 HL029582NHLBI NIH HHS P01 HL103453NHLBI NIH HHS R01 HL096125NHLBI NIH HHS R01HL096125NHLBI NIH HHS R01 HL129763
6 · The paper itself

Abstract

Fungal infection stimulates the canonical C-type lectin receptor (CLR) signaling pathway via activation of the tyrosine kinase Syk. Here we identify a crucial role for the tyrosine phosphatase SHP-2 in mediating CLR-induced activation of Syk. Ablation of the gene encoding SHP-2 (Ptpn11; called 'Shp-2' here) in dendritic cells (DCs) and macrophages impaired Syk-mediated signaling and abrogated the expression of genes encoding pro-inflammatory molecules following fungal stimulation. Mechanistically, SHP-2 operated as a scaffold, facilitating the recruitment of Syk to the CLR dectin-1 or the adaptor FcRγ, through its N-SH2 domain and a previously unrecognized carboxy-terminal immunoreceptor tyrosine-based activation motif (ITAM). We found that DC-derived SHP-2 was crucial for the induction of interleukin 1β (IL-1β), IL-6 and IL-23 and anti-fungal responses of the TH17 subset of helper T cells in controlling infection with Candida albicans. Together our data reveal a mechanism by which SHP-2 mediates the activation of Syk in response to fungal infection.

Indexed as

Amino Acid MotifsAnimalsAntigens, FungalCandidiasisCells, CulturedCytokinesDectin-1Dendritic CellsEnzyme ActivationInflammation MediatorsIntracellular Signaling Peptides and ProteinsLectins, C-TypeLymphocyte ActivationMacrophagesMembrane ProteinsMiceAntigens, FungalClecsf8 protein, mouseCytokinesDectin-1Inflammation MediatorsIntracellular Signaling Peptides and ProteinsLectins, C-TypeMembrane ProteinsProtein-Tyrosine KinasesProtein Tyrosine Phosphatase, Non-Receptor Type 11Receptors, IgESyk KinaseSyk protein, mouse

Identifiers

PMID25915733
PMCPMC4439382
OpenAlexW1990934216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.