ArticleAutophagy2015
Elucidating the composition and conservation of the autophagy pathway in photosynthetic eukaryotes.
Article in Autophagy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- Insights into the Structural and Proteomic Changes inAnimals : an open access journal from MDPI · 2025Article
- A multifunctional organelle coordinates phagocytosis and chlorophagy in a marine eukaryote phytoplankton Scyphosphaera apsteinii.The New phytologist · 2025Article
- Evolutionary conservation and metabolic significance of autophagy in algae.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Tracking of Ubiquitin Signaling through 3.5 Billion Years of Combinatorial Conjugation.International journal of molecular sciences · 2024Review
- The Role of Plant Ubiquitin-like Modifiers in the Formation of Salt Stress Tolerance.Plants (Basel, Switzerland) · 2024Review
- Genomic analysis of an ultrasmall freshwater green alga, Medakamo hakoo.Communications biology · 2023Article
- Evolutionary diversification of the autophagy-related ubiquitin-like conjugation systems.Autophagy · 2022Article
- Deciphering the function and evolution of the target of rapamycin signaling pathway in microalgae.Journal of experimental botany · 2022Article
- Target of Rapamycin Regulates Photosynthesis and Cell Growth inInternational journal of molecular sciences · 2022Article
- To Die or Not to Die-Regulated Cell Death and Survival in Cyanobacteria.Microorganisms · 2022Review
- Article
- A Novel Algicidal Bacterium,Microbiology spectrum · 2022Article
- Role of Autophagy inPlants (Basel, Switzerland) · 2022Article
- Photosynthetic assimilation of COProceedings of the National Academy of Sciences of the United States of America · 2022Article
- An Emiliania huxleyi pan-transcriptome reveals basal strain specificity in gene expression patterns.Scientific reports · 2021Article
- The Autophagy Machinery in Human-Parasitic Protists; Diverse Functions for Universally Conserved Proteins.Cells · 2021Review
- Autophagy in Plant Abiotic Stress Management.International journal of molecular sciences · 2021Review
- Plant Autophagy: An Intricate Process Controlled by Various Signaling Pathways.Frontiers in plant science · 2021Review
- Host and pathogen autophagy are central to the inducible local defences and systemic response of the giant kelp Macrocystis pyrifera against the oomycete pathogen Anisolpidium ectocarpii.The New phytologist · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquatic photosynthetic eukaryotes represent highly diverse groups (green, red, and chromalveolate algae) derived from multiple endosymbiosis events, covering a wide spectrum of the tree of life. They are responsible for about 50% of the global photosynthesis and serve as the foundation for oceanic and fresh water food webs. Although the ecophysiology and molecular ecology of some algal species are extensively studied, some basic aspects of algal cell biology are still underexplored. The recent wealth of genomic resources from algae has opened new frontiers to decipher the role of cell signaling pathways and their function in an ecological and biotechnological context. Here, we took a bioinformatic approach to explore the distribution and conservation of TOR and autophagy-related (ATG) proteins (Atg in yeast) in diverse algal groups. Our genomic analysis demonstrates conservation of TOR and ATG proteins in green algae. In contrast, in all 5 available red algal genomes, we could not detect the sequences that encode for any of the 17 core ATG proteins examined, albeit TOR and its interacting proteins are conserved. This intriguing data suggests that the autophagy pathway is not conserved in red algae as it is in the entire eukaryote domain. In contrast, chromalveolates, despite being derived from the red-plastid lineage, retain and express ATG genes, which raises a fundamental question regarding the acquisition of ATG genes during algal evolution. Among chromalveolates, Emiliania huxleyi (Haptophyta), a bloom-forming coccolithophore, possesses the most complete set of ATG genes, and may serve as a model organism to study autophagy in marine protists with great ecological significance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.