Evidence map›Paper›PMID 25915652›Full record

ArticlePloS one2015

Intelligence in childhood and atherosclerosis of the carotid and peripheral arteries in later life: the Lothian Birth Cohort 1936.

Catharine R Gale, Elizabeth Eadie, Avril Thomas, Mark E Bastin, John M Starr, Joanna Wardlaw, Ian J Deary

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Catharine R GaleCentre for Cognitive Ageing & Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.
Elizabeth EadieCentre for Clinical Brain Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom; Department of Neuroradiology, Western General Hospital, Edinburgh, United Kingdom.
Avril ThomasCentre for Clinical Brain Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom; Department of Neuroradiology, Western General Hospital, Edinburgh, United Kingdom.
Mark E BastinCentre for Cognitive Ageing & Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Clinical Brain Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
John M StarrCentre for Cognitive Ageing & Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Geriatric Medicine Unit, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Joanna WardlawCentre for Cognitive Ageing & Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Clinical Brain Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Ian J DearyCentre for Cognitive Ageing & Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
Western General Hospital · GBUniversity of Edinburgh · GBUniversity of Southampton · GB

Funding

Medical Research Council G0700704Medical Research Council G0701120Medical Research Council G1001245Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/2Medical Research Council MR/K026992/1
6 · The paper itself

Abstract

objectiveThere is some evidence that people who score higher on tests of intelligence in childhood have lower carotid intima-media thickness and higher ankle brachial index in middle age. These findings need replicating in other, older populations. We investigated the prospective relationship between intelligence in childhood and atherosclerosis in the carotid and peripheral arteries at age 73 years.

methodsParticipants were 713 members of the Lothian Birth Cohort 1936 whose intelligence was assessed at age 11 years. At age 73 years, carotid intima-media thickness and degree of stenosis were measured using ultrasound imaging; ankle-brachial index was measured using Doppler ultrasound.

resultsThere were no significant associations between intelligence at age 11 and measures of atherosclerosis at age 73. In age- and sex-adjusted analyses, for a standard deviation higher score in intelligence, intima-media thickness (x 10) was lower by 0.07 (-0.20, 0.06) mm and ankle brachial index (x 10) was lower by 0.09 (-0.24, 0.07); odds ratios for having carotid stenosis >25% or peripheral arterial disease were 0.98 (0.82, 1.16) and 1.05 (0.81, 1.36) respectively.

conclusionIn this study of people aged 73 years, higher childhood intelligence was not associated with reduced risk of atherosclerosis in the carotid or peripheral arteries.

Indexed as

IntelligenceAgedAnkle Brachial IndexAtherosclerosisCarotid Artery DiseasesCarotid Intima-Media ThicknessChildFemaleHumansMalePeripheral Arterial DiseaseProspective StudiesRisk FactorsScotland

Identifiers

PMID25915652
PMCPMC4411126
OpenAlexW2170759980

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.