ArticleeLife2015
Tight Junction Protein 1a regulates pigment cell organisation during zebrafish colour patterning.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Loss-of-function mutations in the melanocortin-2-receptor (mc2r) lead to skin hyperpigmentation in teleost fish.Scientific reports · 2026Article
- Regulatory and disruptive variants in the CLCN2 gene are associated with modified skin color pattern phenotypes in the corn snake.Genome biology · 2025Article
- Linking discrete and continuous models of cell birth and migration.Royal Society open science · 2024Article
- Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2.bioRxiv : the preprint server for biology · 2024Article
- Review
- Comparative transcriptome and miRNA analysis of skin pigmentation during embryonic development of Chinese soft-shelled turtle (Pelodiscus sinensis).BMC genomics · 2022Article
- Pigment pattern morphospace of Danio fishes: evolutionary diversification and mutational effects.Biology open · 2021Article
- Immunoglobulin superfamily receptor Junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes.Developmental biology · 2021Article
- Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos.PLoS genetics · 2021Article
- A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots.PLoS genetics · 2021Article
- Comparative Transcriptome Analysis Identifies Candidate Genes Related to Black-Spotted Pattern Formation in Spotted Scat (Animals : an open access journal from MDPI · 2021Article
- Role of the Connexin C-terminus in skin pattern formation of Zebrafish.BBA advances · 2021Article
- In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning.Nature communications · 2020Article
- Article
- Article
- Comparative transcriptome analysis of trout skin pigment cells.BMC genomics · 2019Article
- Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio).BMC genomics · 2019Article
- Iridophores as a source of robustness in zebrafish stripes and variability in Danio patterns.Nature communications · 2018Article
- ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebrafish display a prominent pattern of alternating dark and light stripes generated by the precise positioning of pigment cells in the skin. This arrangement is the result of coordinated cell movements, cell shape changes, and the organisation of pigment cells during metamorphosis. Iridophores play a crucial part in this process by switching between the dense form of the light stripes and the loose form of the dark stripes. Adult schachbrett (sbr) mutants exhibit delayed changes in iridophore shape and organisation caused by truncations in Tight Junction Protein 1a (ZO-1a). In sbr mutants, the dark stripes are interrupted by dense iridophores invading as coherent sheets. Immuno-labelling and chimeric analyses indicate that Tjp1a is expressed in dense iridophores but down-regulated in the loose form. Tjp1a is a novel regulator of cell shape changes during colour pattern formation and the first cytoplasmic protein implicated in this process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.