ArticlePloS one2015
First report of Clostridium difficile NAP1/027 in a Mexican hospital.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Genomic and phenotypic studies amongMicrobiology spectrum · 2024Article
- An Update onToxins · 2022Review
- Clinical characteristics associated with the severity of Clostridium [Clostridioides] difficile infection in a tertiary teaching hospital from Mexico.Biomedical journal · 2022Article
- Molecular Epidemiology and Antimicrobial Resistance ofFrontiers in microbiology · 2021Article
- Phenotypical and Genotypical Comparison ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- Spo0A SuppressesmSphere · 2020Article
- Screening of biomarkers of drug resistance or virulence in ESCAPE pathogens by MALDI-TOF mass spectrometry.Scientific reports · 2019Article
- Phenotypic Characterization of Non-toxigenicFrontiers in microbiology · 2019Article
- Article
- Article
- Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages.Journal of clinical microbiology · 2017Article
- Predictors of severe outcomes in patients with Clostridium difficile infection from a Hispanic population.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Article
- Clostridium difficile Infection.Microbiology spectrum · 2016Review
- Article
- Increasing rates of Clostridium difficile infection in Mexican hospitals.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesObservational
- Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
- Erratum issuedCorrection: First Report of Clostridium difficile NAP1/027 in a Mexican Hospital.2015 · Garza, Héctor J Maldonado [corrected to Maldonado-Garza, Héctor J]
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveClostridium difficile NAP1/ribotype 027 is associated with severe disease and high mortality rates. Our aim was to determine the prevalence of NAP1/ribotype 027 among C. difficile isolates in a tertiary care hospital, and review the main clinical data.
methodsWe included 106 stool samples from 106 patients. Samples were tested for A&B toxins and were cultured on CCFA agar. The genes tcdA, tcdB, tcdC, cdtA, and cdtB were amplified using PCR in clinical isolates. The tcdA 3'-end deletion analysis, PCR-ribotyping, and pulsed-field gel electrophoresis (PFGE) were also performed. Stool samples that were positive for culture were tested by the GeneXpert C. difficile assay. Clinical data were collected.
resultsThirty-six patients tested positive for A&B toxins; and 22 patients had positive culture for C. difficile, 14 of which tested positive for the A&B toxins and all 22 patients tested positive by the GeneXpert C. difficile assay. Risk factors included an average hospital stay of 16.1 days prior to toxin detection, average antibiotic use for 16.2 days, and a median of 3 antibiotics used. The 30-day crude mortality rate was 8.4%. Six of the 22 patients died, and 3 of those deaths were directly attributed to C. difficile infection. The majority of isolates, 90.9% (20/22), carried genes tcdB, tcdA, cdtA, and cdtB; and these strains carried the corresponding downregulator gene tcdC, with an 18-bp deletion. PFGE was performed on 17 isolates, and one main pattern was observed. Analysis of the ribotyping data showed similar results.
conclusionThe above findings represent the clonal spread of C. difficile in our institution, which mainly includes the NAP1/027 strain. This is the first report of C. difficile ribotype NAP1/027 in Mexico.
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