Evidence map›Paper›PMID 25915540›Full record

ArticlePloS one2015

The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma.

Fabiana Salm, Valeriya Dimitrova, André O von Bueren, Paulina Ćwiek, Hubert Rehrauer, Valentin Djonov, Pascale Anderle, Alexandre Arcaro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  6. Review
  7. Article
  8. Review
  9. Article
  10. The Non-coding Side of Medulloblastoma.Frontiers in cell and developmental biology · 2020
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. miR-125b suppresses the proliferation of hepatocellular carcinoma cells by targeting Sirtuin7.International journal of clinical and experimental medicine · 2015
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Fabiana SalmDepartment of Clinical Research, Division of Pediatric Hematology/Oncology, University of Bern, Bern, Switzerland.
Valeriya DimitrovaDepartment of Clinical Research, Division of Pediatric Hematology/Oncology, University of Bern, Bern, Switzerland.
André O von BuerenDepartment of Pediatrics and Department of Pediatric Hematology and Oncology, Georg August University Goettingen, Goettingen, Germany.
Paulina ĆwiekDepartment of Clinical Research, Division of Pediatric Hematology/Oncology, University of Bern, Bern, Switzerland.
Hubert RehrauerFunctional Genomics Center Zurich, ETH and University of Zurich, Zurich, Switzerland.
Valentin DjonovInstitute of Anatomy, University of Bern, Bern, Switzerland.
Pascale AnderleInstitute of Biochemistry and Molecular Medicine, University of Bern, Swiss National Centre of Competence in Research TransCure, University of Bern, Bern, Switzerland; Swiss National Centre of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Alexandre ArcaroDepartment of Clinical Research, Division of Pediatric Hematology/Oncology, University of Bern, Bern, Switzerland.
University of Bern · CHSIB Swiss Institute of Bioinformatics · CHUniversity of Göttingen · DEUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medulloblastoma (MB) is the most common malignant brain tumor in childhood and represents the main cause of cancer-related death in this age group. The phosphoinositide 3-kinase (PI3K) pathway has been shown to play an important role in the regulation of medulloblastoma cell survival and proliferation, but the molecular mechanisms and downstream effectors underlying PI3K signaling still remain elusive. The impact of RNA interference (RNAi)-mediated silencing of PI3K isoforms p110α and p110δ on global gene expression was investigated by DNA microarray analysis in medulloblastoma cell lines. A subset of genes with selectively altered expression upon p110α silencing in comparison to silencing of the closely related p110δ isoform was revealed. Among these genes, the leukemia inhibitory factor receptor α (LIFR α) was validated as a novel p110α target in medulloblastoma. A network involving c-Myc and miR-125b was shown to be involved in the control of LIFRα expression downstream of p110α. Targeting the LIFRα by RNAi, or by using neutralizing reagents impaired medulloblastoma cell proliferation in vitro and induced a tumor volume reduction in vivo. An analysis of primary tumors revealed that LIFRα and p110α expression were elevated in the sonic hedgehog (SHH) subgroup of medulloblastoma, indicating its clinical relevance. Together, these data reveal a novel molecular signaling network, in which PI3K isoform p110α controls the expression of LIFRα via c-Myc and miR-125b to promote MB cell proliferation.

Indexed as

Cell ProliferationCell Line, TumorClass Ia Phosphatidylinositol 3-KinaseGene Expression Regulation, NeoplasticHumansIsoenzymesMedulloblastomaMicroRNAsProto-Oncogene Proteins c-mycReceptors, OSM-LIFClass Ia Phosphatidylinositol 3-KinaseIsoenzymesMicroRNAsMIRN125 microRNA, humanProto-Oncogene Proteins c-mycReceptors, OSM-LIF

Identifiers

PMID25915540
PMCPMC4411098
OpenAlexW2090476365

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.