Evidence map›Paper›PMID 25915535›Full record

ArticleOncotarget2015

Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma.

Britt Lauenborg, Louise Christensen, Ulrik Ralfkiaer, Katharina L Kopp, Lars Jønson, Sally Dabelsteen, Charlotte M Bonefeld, Carsten Geisler, Lise Mette R Gjerdrum, Qian Zhang and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Britt LauenborgDepartment of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Louise ChristensenDepartment of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Ulrik RalfkiaerDepartment of Hematology, Copenhagen University Hospital, Copenhagen, Denmark.
Katharina L KoppDepartment of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Lars JønsonCenter for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Sally DabelsteenDepartment of Oral Medicine and Pathology, School of Dentistry, University of Copenhagen, Copenhagen, Denmark.
Charlotte M BonefeldDepartment of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Carsten GeislerDepartment of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Lise Mette R GjerdrumDepartment of Pathology, Roskilde Hospital, Roskilde, Denmark.
Qian ZhangDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mariusz A WasikDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Elisabeth RalfkiaerDepartment of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.
Niels ØdumDepartment of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Anders WoetmannDepartment of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DKCopenhagen University Hospital · DKUniversity of Pennsylvania · USRoskilde Sygehus · DK

Funding

Jak/STAT signaling in human T-cell lymphomasR01CA089194 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WASIK, MARIUSZ A. · 2001 to 2010
$2.5M
NCI NIH HHS CA89194NCI NIH HHS R01 CA089194
6 · The paper itself

Abstract

Lymphotoxin α (LTα) plays a key role in the formation of lymphatic vasculature and secondary lymphoid structures. Cutaneous T cell lymphoma (CTCL) is the most common primary lymphoma of the skin and in advanced stages, malignant T cells spreads through the lymphatic to regional lymph nodes to internal organs and blood. Yet, little is known about the mechanism of the CTCL dissemination. Here, we show that CTCL cells express LTα in situ and that LTα expression is driven by aberrantly activated JAK3/STAT5 pathway. Importantly, via TNF receptor 2, LTα functions as an autocrine factor by stimulating expression of IL-6 in the malignant cells. LTα and IL-6, together with VEGF promote angiogenesis by inducing endothelial cell sprouting and tube formation. Thus, we propose that LTα plays a role in malignant angiogenesis and disease progression in CTCL and may serve as a therapeutic target in this disease.

Indexed as

AdultAgedAged, 80 and overBinding SitesDNA-Binding ProteinsEndothelial CellsFemaleHumansHuman Umbilical Vein Endothelial CellsInterleukin-6Janus Kinase 3Lymphatic MetastasisLymphoma, T-Cell, CutaneousLymphotoxin-alphaMaleMiddle AgedDNA-Binding ProteinsIL6 protein, humanInterleukin-6JAK3 protein, humanJanus Kinase 3Lymphotoxin-alphaNF-kappa BReceptors, Tumor Necrosis Factor, Type IIRNA, Small InterferingSTAT5A protein, humanSTAT5B protein, humanSTAT5 Transcription FactorTumor Suppressor ProteinsVascular Endothelial Growth Factor AVEGFA protein, humanangiogenesisCTCLLTA

Identifiers

PMID25915535
PMCPMC4558148
OpenAlexW1945085852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.