Evidence map›Paper›PMID 25915414›Full record

ArticlePloS one2015

Susceptibility-Weighted Imaging Manifestations in the Brain of Wilson's Disease Patients.

Jinjing Yang, Xiaohu Li, Renmin Yang, Xuen Yu, Changliang Yu, Yinfeng Qian, Yongqiang Yu

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Neurologic impairment in Wilson disease.Annals of translational medicine · 2019
    Review
  10. Article
  11. Oxidative stress measured in vivo without an exogenous contrast agent using QUEST MRI.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018
    Review
  12. Magnetic Susceptibility Changes in the Basal Ganglia and Brain Stem of Patients with Wilson's Disease: Evaluation with Quantitative Susceptibility Mapping.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2018
    Article
  13. Wilson's Disease in China.Neuroscience bulletin · 2017
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jinjing YangDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Xiaohu LiDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Renmin YangDepartment of Neurology, The Hospital Affiliated of Anhui College of TCM, Hefei, China.
Xuen YuDepartment of Neurology, The Hospital Affiliated of Anhui College of TCM, Hefei, China.
Changliang YuDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yinfeng QianDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yongqiang YuDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Anhui Medical University · CNAffiliated Hospital of Jiangxi College of TCM · CNFirst Affiliated Hospital of Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIt is well known that patients with Wilson's disease (WD) suffer copper metabolism disorder. However, recent studies point to an additional iron metabolism disorder in WD patients. The purpose of our study was to examine susceptibility-weighted imaging (SWI) manifestations of WD in the brains of WD patients.

methodsA total of 33 patients with WD and 18 normal controls underwent conventional MRI (Magnetic resonance imaging) and SWI. The phase values were measured on SWI-filtered phase images of the bilateral head of the caudate nuclei, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus. Student's t-tests were used to compare the phase values between WD groups and normal controls.

resultsThe mean phase values for the bilateral head of the caudate nuclei, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus were significantly lower than those in the control group (P < 0.001), and bilateral putamen was most strongly affected.

conclusionsThere is paramagnetic mineralization deposition in brain gray nuclei of WD patients and SWI is an effective method to evaluate these structures.

Indexed as

AdolescentAdultBrainChildCopperDisease SusceptibilityFemaleHepatolenticular DegenerationHumansMagnetic Resonance ImagingMaleMetabolic DiseasesYoung AdultCopper

Identifiers

PMID25915414
PMCPMC4411130
OpenAlexW1990791884

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.