Evidence map›Paper›PMID 25915177›Full record

ReviewInfectious diseases (London, England)2015

Nontuberculous mycobacterial osteomyelitis.

Sheng Bi, Fei-Shu Hu, Hai-Ying Yu, Kai-Jin Xu, Bei-Wen Zheng, Zhong-Kang Ji, Jun-Jie Li, Mei Deng, Hai-Yang Hu, Ji-Fang Sheng

Abstract readReview
In one paragraph

Review in Infectious diseases (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Frontiers in cellular and infection microbiology · 2026
    Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. A Rare Case of Osteomyelitis of an Ankle Caused byAntibiotics (Basel, Switzerland) · 2023
    Article
  10. Coexistence ofFrontiers in microbiology · 2023
    Article
  11. IDCases · 2023
    Article
  12. Vertebral Osteomyelitis Caused byOpen forum infectious diseases · 2023
    Article
  13. [Clinical Characteristics of Nontuberculous Mycobacterium Infection Cases in Sichuan, China in 2016-2021: A Retrospective Study].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. BMJ case reports · 2020
    Article
  19. Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sheng BiFrom the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University , Hangzhou , China.
Fei-Shu Hu
Hai-Ying Yu
Kai-Jin Xu
Bei-Wen Zheng
Zhong-Kang Ji
Jun-Jie Li
Mei Deng
Hai-Yang Hu
Ji-Fang Sheng

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteomyelitis caused by nontuberculous mycobacteria (NTM) can have severe consequences and a poor prognosis. Physicians therefore need to be alert to this condition, especially in immunocompromised patients. Although the pathogenesis of NTM osteomyelitis is still unclear, studies in immunodeficient individuals have revealed close relationships between NTM osteomyelitis and defects associated with the interleukin-12-interferon-γ-tumor necrosis factor-α axis, as well as human immunodeficiency virus infection, various immunosuppressive conditions, and diabetes mellitus. Culture and species identification from tissue biopsies or surgical debridement tissue play crucial roles in diagnosing NTM osteomyelitis. Suitable imaging examinations are also important. Adequate surgical debridement and the choice of appropriate, combined antibiotics for long-term anti-mycobacterial chemotherapy, based on in vitro drug susceptibility tests, are the main therapies for these bone infections. Bacillus Calmette-Guerin vaccination might have limited prophylactic value. The use of multiple drugs and long duration of treatment mean that the therapeutic process needs to be monitored closely to detect potential side effects. Adequate duration of anti-mycobacterial chemotherapy together with regular monitoring with blood and imaging tests are key factors determining the recovery outcome in patients with NTM osteomyelitis.

Indexed as

AdultDiabetes ComplicationsDiabetes MellitusDisease SusceptibilityHIVHumansImmunocompromised HostInterferon-gammaInterleukin-12Mycobacterium Infections, NontuberculousNontuberculous MycobacteriaOsteomyelitisTumor Necrosis Factor-alphaInterferon-gammaInterleukin-12Tumor Necrosis Factor-alphadiabetes mellitusnontuberculous mycobacteriaOsteomyelitis

Identifiers

PMID25915177
PMCPMC4714132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.