ArticleJournal of the American Chemical Society2015
Conformational Switching of a Foldamer in a Multicomponent System by pH-Filtered Selection between Competing Noncovalent Interactions.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hydrogen Bonding within DynamicJournal of the American Chemical Society · 2026Article
- Planar Lipid Bilayers and Liposomes: Essential Models for Advancing Protein Structure and Function Research.Advances in experimental medicine and biology · 2026Review
- Modular synthesis of zinc(II)-bis(triazole) recognition sites for the conformational control of foldamers.Organic & biomolecular chemistry · 2025Article
- Oriented triplex DNA as a synthetic receptor for transmembrane signal transduction.Nature communications · 2024Article
- Stimulus-Induced Relief of Intentionally Incorporated Frustration Drives Refolding of a Water-Soluble Biomimetic Foldamer.Journal of the American Chemical Society · 2023Article
- Anion-Dependent Hydrogen-Bond Polarity Switching in Ethylene-bridged Urea Oligomers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Non-Covalent Interactions Enforce Conformation in Switchable and Water-Soluble Diketopiperazine-Pyridine Foldamers.Angewandte Chemie (International ed. in English) · 2023Article
- Switching imidazole reactivity by dynamic control of tautomer state in an allosteric foldamer.Nature communications · 2023Article
- Screw sense and screw sensibility: communicating information by conformational switching in helical oligomers.Chemical Society reviews · 2023Review
- Inducing a pH-dependent conformational response by competitive binding to ZnChemical science · 2022Article
- α-Amino-iso-Butyric Acid Foldamers Terminated with Rhodium(I) N-Heterocyclic Carbene Catalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Controlling the conformational stability of coiled-coil peptides with a single stereogenic center of a peripheral β-amino acid residue.RSC advances · 2022Article
- Linear Dichroism Activity of Chiral Poly(ACS omega · 2021Article
- Article
- Supramolecular chemistry in lipid bilayer membranes.Chemical science · 2021Review
- Engineering of stimuli-responsive lipid-bilayer membranes using supramolecular systems.Nature reviews. Chemistry · 2021Review
- Molecular Recognition by Zn(II)-Capped Dynamic Foldamers.ChemistryOpen · 2020Article
- Bis-pyrene probes of foldamer conformation in solution and in phospholipid bilayers.Chemical science · 2018Article
- A spin-1 representation for dual-funnel energy landscapes.The Journal of chemical physics · 2018Article
- Supramolecular chemistry: Host in translation.Nature nanotechnology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Biomolecular systems are able to respond to their chemical environment through reversible, selective, noncovalent intermolecular interactions. Typically, these interactions induce conformational changes that initiate a signaling cascade, allowing the regulation of biochemical pathways. In this work, we describe an artificial molecular system that mimics this ability to translate selective noncovalent interactions into reversible conformational changes. An achiral but helical foldamer carrying a basic binding site interacts selectively with the most acidic member of a suite of chiral ligands. As a consequence of this noncovalent interaction, a global absolute screw sense preference, detectable by (13)C NMR, is induced in the foldamer. Addition of base, or acid, to the mixture of ligands competitively modulates their interaction with the binding site, and reversibly switches the foldamer chain between its left and right-handed conformations. As a result, the foldamer-ligand mixture behaves as a biomimetic chemical system with emergent properties, functioning as a "proton-counting" molecular device capable of providing a tunable, pH-dependent conformational response to its environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.