ArticleTissue engineering. Part C, Methods2015
Hemodynamic Characterization of a Mouse Model for Investigating the Cellular and Molecular Mechanisms of Neotissue Formation in Tissue-Engineered Heart Valves.
Article in Tissue engineering. Part C, Methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Hemodynamic forces prevent myxomatous valve disease in mice through KLF2/4 signaling.The Journal of clinical investigation · 2025Article
- Tissue Engineered Transcatheter Pulmonary Valved Stent Implantation: Current State and Future Prospect.International journal of molecular sciences · 2022Review
- Preclinical Assessment of Cardiac Valve Substitutes: Current Status and Considerations for Engineered Tissue Heart Valves.Frontiers in cardiovascular medicine · 2019Review
- Tissue-Engineered Heart Valves: A Call for Mechanistic Studies.Tissue engineering. Part B, Reviews · 2018Article
- The Heart and Great Vessels.Cold Spring Harbor perspectives in medicine · 2018Review
- Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs.Nature communications · 2016Article
- Cardiovascular Tissue Engineering: Preclinical Validation to Bedside Application.Physiology (Bethesda, Md.) · 2016Review
- Recellularization of decellularized heart valves: Progress toward the tissue-engineered heart valve.Journal of tissue engineeringReview
- Tissue-engineered composite tracheal grafts create mechanically stable and biocompatible airway replacements.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Decellularized allograft heart valves have been used as tissue-engineered heart valve (TEHV) scaffolds with promising results; however, little is known about the cellular mechanisms underlying TEHV neotissue formation. To better understand this phenomenon, we developed a murine model of decellularized pulmonary heart valve transplantation using a hemodynamically unloaded heart transplant model. Furthermore, because the hemodynamics of blood flow through a heart valve may influence morphology and subsequent function, we describe a modified loaded heterotopic heart transplant model that led to an increase in blood flow through the pulmonary valve. We report host cell infiltration and endothelialization of implanted decellularized pulmonary valves (dPV) and provide an experimental approach for the study of TEHVs using mouse models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.